Apoptosis and apoptotic body: disease message and therapeutic target potentials

X Xu, Y Lai, ZC Hua - Bioscience reports, 2019 - portlandpress.com
Apoptosis is widely known as programmed cell death eliciting no inflammatory responses.
The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth …

B cells in the pathogenesis of primary Sjögren syndrome

G Nocturne, X Mariette - Nature Reviews Rheumatology, 2018 - nature.com
Primary Sjögren syndrome (pSS) is a prototypical autoimmune disease. The involvement of
B cells in the pathogenesis of pSS has long been suspected on the basis of clinical …

Advances in understanding the pathogenesis of primary Sjögren's syndrome

G Nocturne, X Mariette - Nature Reviews Rheumatology, 2013 - nature.com
Primary Sjögren's syndrome (pSS) is a prototypic autoimmune disorder, management of
which has long suffered from a lack of knowledge of the underlying pathophysiological …

The role of defective clearance of apoptotic cells in systemic autoimmunity

LE Muñoz, K Lauber, M Schiller, AA Manfredi… - Nature Reviews …, 2010 - nature.com
The inefficient clearance of dying cells can result in the accumulation of apoptotic cell
remnants. This occurrence is considered an intrinsic defect that can cause the permanent …

Autoantibodies in Sjögren's syndrome

A Fayyaz, BT Kurien… - Rheumatic Disease …, 2016 - rheumatic.theclinics.com
Sjogren's syndrome is characterized by the presence of a plethora of autoantibodies (Table
1). We herein review major recent development in autoantibodies associated with Sjogren …

Autoantibodies in SLE: specificities, isotypes and receptors

B Dema, N Charles - Antibodies, 2016 - mdpi.com
Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-
antibodies which recognize several cellular components. The production of these self …

Definition of human autoimmunity—autoantibodies versus autoimmune disease

A Lleo, P Invernizzi, B Gao, M Podda, ME Gershwin - Autoimmunity reviews, 2010 - Elsevier
The critical function of the immune system is to discriminate self from non-self. Tolerance
against self-antigens is a highly regulated process and, in order to maintain it, the immune …

The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

T Hung, GA Pratt, B Sundararaman, MJ Townsend… - Science, 2015 - science.org
Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE)
and Sjögren's syndrome. However, it is unclear whether Ro60 and its associated RNAs …

Benefits and risks of IgG transplacental transfer

AM Ciobanu, AE Dumitru, N Gica, R Botezatu… - Diagnostics, 2020 - mdpi.com
Maternal passage of immunoglobulin G (IgG) is an important passive mechanism for
protecting the infant while the neonatal immune system is still immature and ineffective. IgG …

Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block

H Suryawanshi, R Clancy, P Morozov… - Cardiovascular …, 2020 - academic.oup.com
Aims Investigating human heart development and applying this to deviations resulting in
disease is incomplete without molecular characterization of the cell types required for …