Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

A better understanding of COVID-19 in people with primary immunodeficiency (PI), rare
inherited defects in the immune system, is important for protecting this population, especially …

Background Profound lymphopenia is an independent predictor of adverse clinical
outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival …

Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

Background In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection
is characterized by major immune dysfunctions. The capacity of these severe patients to …

IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of
many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to an unprecedented global healthcare crisis. While SARS-CoV-2-associated COVID-19 …

A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a
state of immunosuppression contributing to their worsening. A novel virotherapy based on …

Repeated pandemics caused by the influenza virus and severe acute respiratory syndrome
coronavirus (SARS-CoV) have resulted in serious problems in global public health …

The role of IL-7 and IL-7R for normal lymphoid development and an adequately functioning
immune system has been recognized for long, with severe immune deficiency and lymphoid …