C Trépo, HLY Chan, A Lok - The Lancet, 2014 - thelancet.com
Hepatitis B virus infection is a major public health problem worldwide; roughly 30% of the world's population show serological evidence of current or past infection. Hepatitis B virus is …
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease. There is uncertainty around the economic burden of NAFLD. We constructed a steady‐state …
SK Sarin, M Kumar, GK Lau, Z Abbas, HLY Chan… - Hepatology …, 2016 - Springer
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection …
M Buti, E Gane, WK Seto, HLY Chan… - The lancet …, 2016 - thelancet.com
Background The novel prodrug tenofovir alafenamide delivers the nucleotide reverse transcriptase inhibitor tenofovir to target cells more efficiently at a lower dose than tenofovir …
Chronic hepatitis B viral (HBV) infection remains a significant global health problem. Evidence‐based guidelines are needed to help providers determine when treatment should …
Since active hepatitis B virus (HBV) replication is the key driver of hepatic necroinflammation and disease progression, the treatment aim of chronic hepatitis B (CHB) is to suppress HBV …
HLY Chan, S Fung, WK Seto, WL Chuang… - The lancet …, 2016 - thelancet.com
Background Tenofovir alafenamide is a novel prodrug formulated to deliver the active metabolite to target cells more efficiently than tenofovir disoproxil fumarate at a lower dose …
RP Perrillo, R Gish, YT Falck-Ytter - Gastroenterology, 2015 - gastrojournal.org
This article has an accompanying continuing medical education activity on page e16. Learning Objective: Upon completion of the CME activity, successful learners will be able to …
In the treatment of chronic hepatitis B (CHB), the ultimate goal is preventing hepatitis B virus (HBV)-associated liver disease, including hepatocellular carcinoma (HCC). Recently …