Risk factors of severe COVID-19: a review of host, viral and environmental factors
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …
asymptomatic infections to severe disease and death. Understanding the risk factors of …
COVID‐19 immunopathology: from acute diseases to chronic sequelae
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …
as a primary affected organ, which is also a critical site of immune cell activation by severe …
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
J Muri, V Cecchinato, A Cavalli, AA Shanbhag… - Nature …, 2023 - nature.com
Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse
symptoms, which can persist for months. While antiviral antibodies are protective, those …
symptoms, which can persist for months. While antiviral antibodies are protective, those …
[PDF][PDF] SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice
FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …
Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19
R Sparks, WW Lau, C Liu, KL Han, KL Vrindten, G Sun… - Nature, 2023 - nature.com
Acute viral infections can have durable functional impacts on the immune system long after
recovery, but how they affect homeostatic immune states and responses to future …
recovery, but how they affect homeostatic immune states and responses to future …
COVID-19 disease and immune dysregulation
E Davitt, C Davitt, MB Mazer, SS Areti… - Best Practice & …, 2022 - Elsevier
The SARS-CoV-2 virus has complex and divergent immune alterations in differing hosts and
over disease evolution. Much of the nuanced COVID-19 disease immune dysregulation was …
over disease evolution. Much of the nuanced COVID-19 disease immune dysregulation was …
Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients
JJ Engel, CI van der Made, N Keur… - Frontiers in …, 2023 - frontiersin.org
Background Dexamethasone improves the survival of COVID-19 patients in need of
supplemental oxygen therapy. Although its broad immunosuppressive effects are well …
supplemental oxygen therapy. Although its broad immunosuppressive effects are well …
[HTML][HTML] Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which causes
coronavirus-19 (COVID-19), has caused significant morbidity and mortality globally. In …
coronavirus-19 (COVID-19), has caused significant morbidity and mortality globally. In …
[HTML][HTML] Neutrophil extracellular traps and long COVID
A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …
systemic symptoms experienced by a significant number of COVID-19 survivors. The …
A complement atlas identifies interleukin-6–dependent alternative pathway dysregulation as a key druggable feature of COVID-19
KFA Van Damme, L Hoste, J Declercq… - Science Translational …, 2023 - science.org
Improvements in COVID-19 treatments, especially for the critically ill, require deeper
understanding of the mechanisms driving disease pathology. The complement system is not …
understanding of the mechanisms driving disease pathology. The complement system is not …