Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination

SJ Theobald, A Simonis, JM Mudler… - EMBO Molecular …, 2022 - embopress.org
Durable cell‐mediated immune responses require efficient innate immune signaling and the
release of pro‐inflammatory cytokines. How precisely mRNA vaccines trigger innate immune …

[HTML][HTML] Modulation of innate immunity in airway epithelium for host-directed therapy

IT Myszor, GH Gudmundsson - Frontiers in Immunology, 2023 - frontiersin.org
Innate immunity of the mucosal surfaces provides the first-line defense from invading
pathogens and pollutants conferring protection from the external environment. Innate …

Association between vitamin D levels and inflammatory markers in COVID-19 patients: a meta-analysis of observational studies

R Hopefl, M Ben-Eltriki, S Deb - Journal of Pharmacy & …, 2022 - journals.library.ualberta.ca
Purpose: Vitamin D has immunomodulatory properties that can be useful in COVID-19
patients. We performed a meta-analysis of observational studies to analyze the association …

[HTML][HTML] SARS-CoV-2 N protein induced acute kidney injury in diabetic db/db mice is associated with a Mincle-dependent M1 macrophage activation

W Wu, W Wang, L Liang, J Chen, S Sun, B Wei… - Frontiers in …, 2023 - frontiersin.org
“Cytokine storm” is common in critically ill COVID-19 patients, however, mechanisms remain
largely unknown. Here, we reported that overexpression of SARS-CoV-2 N protein in …

[HTML][HTML] Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

TR Ullah, MD Johansen, KR Balka, RL Ambrose… - Nature …, 2023 - nature.com
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of
type-I interferons, which have essential antiviral activities, including against SARS-CoV-2 …

Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling

Y Sun, V Nascimento Da Conceicao… - Clinical and …, 2023 - Wiley Online Library
Abstract Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease
that is embodied by the loss of salivary gland function and immune cell infiltration, but the …

[HTML][HTML] A real Pandora's box in pandemic times: a narrative review on the acute cardiac injury due to COVID-19

AS Timpau, RS Miftode, D Leca, R Timpau, IL Miftode… - Life, 2022 - mdpi.com
The intricate relationship between severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) and the cardiovascular system is an extensively studied pandemic topic, as there is …

[HTML][HTML] Immunosuppressant therapies in COVID-19: is the TNF axis an alternative?

Y Palacios, L Chavez-Galan - Pharmaceuticals, 2022 - mdpi.com
The study of cytokine storm in COVID-19 has been having different edges in accordance
with the knowledge of the disease. Various cytokines have been the focus, especially to …

[HTML][HTML] Gas6/TAM axis involvement in modulating inflammation and fibrosis in COVID-19 patients

M Rizzi, S Tonello, D D'Onghia… - International Journal of …, 2023 - mdpi.com
Gas6 (growth arrest-specific gene 6) is a widely expressed vitamin K-dependent protein that
is involved in many biological processes such as homeostatic regulation, inflammation and …

[HTML][HTML] Insights into CD24 and exosome physiology and potential role in view of recent advances in COVID-19 therapeutics: a narrative review

G Tsioulos, I Grigoropoulos, CD Moschopoulos… - Life, 2022 - mdpi.com
Cluster of differentiation (CD) 24, a long-known protein with multifaceted functions, has
gained attention as a possible treatment for Coronavirus Disease 19 (COVID-19) due to its …