Upregulation of PD‐L1 by SARS‐CoV‐2 promotes immune evasion

HC Huang, SH Wang, GC Fang… - Journal of Medical …, 2023 - Wiley Online Library
Patients with severe COVID‐19 often suffer from lymphopenia, which is linked to T‐cell
sequestration, cytokine storm, and mortality. However, it remains largely unknown how …

The role of influenza A virus-induced hypercytokinemia

F Wei, C Gao, Y Wang - Critical Reviews in Microbiology, 2022 - Taylor & Francis
Influenza viruses are one of the leading causes of respiratory tract infections in humans and
their newly emerging and re-emerging virus strains are responsible for seasonal epidemics …

[HTML][HTML] Clinical significance of antineutrophil cytoplasmic antibody positivity in patients infected with SARS-CoV-2

LE Lee, W Jeong, YB Park, SJ Jeong… - Journal of Clinical …, 2022 - mdpi.com
Objectives: To investigate the rate of antineutrophil cytoplasmic antibody (ANCA) positivity
and its clinical significance in patients infected with severe acute respiratory syndrome …

[HTML][HTML] Population pharmacokinetics of dexamethasone in critically ill COVID-19 patients: Does inflammation play a role?

L Li, S Sassen, N Hunfeld, T Smeets, T Ewoldt… - Journal of Critical …, 2023 - Elsevier
Purpose The aim of this study is to design a population pharmacokinetic study to gain a
deeper understanding of the pharmacokinetics of dexamethasone in critically ill COVID-19 …

[HTML][HTML] Nucleoside analogs that inhibit SARS-CoV-2 replication by blocking interaction of virus polymerase with RNA

E Matyugina, I Petushkov, S Surzhikov, V Kezin… - International Journal of …, 2023 - mdpi.com
The SARS-CoV-2 betacoronavirus pandemic has claimed more than 6.5 million lives and,
despite the development and use of COVID-19 vaccines, remains a major global public …

[HTML][HTML] Pleiotropic Functions of Nitric Oxide Produced by Ascorbate for the Prevention and Mitigation of COVID-19: A Revaluation of Pauling's Vitamin C Therapy

H Yamasaki, H Imai, A Tanaka, JM Otaki - Microorganisms, 2023 - mdpi.com
Linus Pauling, who was awarded the Nobel Prize in Chemistry, suggested that a high dose
of vitamin C (l-ascorbic acid) might work as a prevention or treatment for the common cold …

Secretome of EMSCs neutralizes LPS‑induced acute lung injury via aerosol administration

J Tan, Z Zhuo, X Wang, Y Zhang… - International …, 2023 - spandidos-publications.com
Ectodermal mesenchymal stem cells (EMSCs) are cells harvested from the stem cell niche
(nasal mucosa) with high therapeutic potential. To the best of our knowledge, however, the …

[HTML][HTML] Pre-existing lymphopenia increases the risk of hospitalization and death after SARS-CoV-2 infection

R Garbo, F Valent, GL Gigli, M Valente - Infectious Disease Reports, 2022 - mdpi.com
There is limited information regarding the severity of COVID-19 in immunocompromized
patients. We conducted a retrospective cohort study considering the period from 1 March …

COVID-19 as a polymorphic inflammatory spectrum of diseases: a review with focus on the brain

SW Tang, DM Helmeste, BE Leonard - Acta Neuropsychiatrica, 2023 - cambridge.org
There appear to be huge variations and aberrations in the reported data in COVID-19 2
years now into the pandemic. Conflicting data exist at almost every level and also in the …

The infected lungs and brain Interface in COVID-19: the impact on cognitive function

L Joaquim, A Della Giustina, RS Machado… - …, 2022 - karger.com
Abstract Many coronavirus disease 2019 (COVID-19)-recovered patients report signs and
symptoms and are experiencing neurological, psychiatric, and cognitive problems. However …