[HTML][HTML] Is nuclear factor erythroid 2-related factor 2 a target for the intervention of cytokine storms?

Z Liu, P Deng, S Liu, Y Bian, Y Xu, Q Zhang, H Wang… - Antioxidants, 2023 - mdpi.com
The term “cytokine storm” describes an acute pathophysiologic state of the immune system
characterized by a burst of cytokine release, systemic inflammatory response, and multiple …

[HTML][HTML] Infection with the SARS-CoV-2 B. 1.351 variant is lethal in aged BALB/c mice

F Yasui, Y Matsumoto, N Yamamoto, T Sanada… - Scientific Reports, 2022 - nature.com
Abstract Models of animals that are susceptible to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection can usefully evaluate the efficacy of vaccines and …

Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism

L Li, W Xu, Y Luo, C Lao, X Tong, J Du, B Huang… - Carbohydrate …, 2022 - Elsevier
The cytokine storm is highly associated with inflammatory-type disease severity and patients'
survival. Plant polysaccharides, the main natural phytomedicine source, have a great …

[HTML][HTML] The potential role of cytokine storm pathway in the clinical course of viral respiratory pandemic

G Murdaca, F Paladin, A Tonacci, S Isola, A Allegra… - Biomedicines, 2021 - mdpi.com
The “cytokine storm”(CS) consists of a spectrum of different immune dysregulation disorders
characterized by constitutional symptoms, systemic inflammation and multiorgan dysfunction …

[HTML][HTML] Research progress of post-acute sequelae after SARS-CoV-2 infection

T Jiao, Y Huang, H Sun, L Yang - Cell Death & Disease, 2024 - nature.com
SARS-CoV-2 has spread rapidly worldwide and infected hundreds of millions of people
worldwide. With the increasing number of COVID-19 patients discharged from hospitals, the …

[HTML][HTML] Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Compounds Oleacin and Oleuropein-Aglycone on Senescent Endothelial and Small Airway …

A Silvestrini, C Giordani, S Bonacci, A Giuliani… - Antioxidants, 2023 - mdpi.com
Olive tree by-products have been deeply studied as an invaluable source of bioactive
compounds. Several in vitro and in vivo studies showed that olive leaf extract (OLE) has anti …

Discovery of a Series of 5-Amide-1H-pyrazole-3-carboxyl Derivatives as Potent P2Y14R Antagonists with Anti-Inflammatory Characters

Y Wang, M Zhou, T Ye, P Wang, R Lu… - Journal of Medicinal …, 2022 - ACS Publications
UDPG/P2Y14R signaling pathway has been considered as a potential therapeutic target for
innate immune system diseases. Based on the scaffold hopping strategy, a series of …

5-HT/CGRP pathway and Sumatriptan role in Covid-19

HM Al-Kuraishy, AI Al-Gareeb, A Alexiou… - Biotechnology and …, 2022 - Taylor & Francis
ABSTRACT Coronavirus disease 2019 (Covid-19) is a pandemic caused by severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2). In Covid-19, there is uncontrolled …

Up-regulated serum levels of interleukin (IL)-17A and IL-22 in Egyptian pediatric patients with COVID-19 and MIS-C: Relation to the disease outcome

GA Mostafa, HM Ibrahim, AAS Shehab, SM Magdy… - Cytokine, 2022 - Elsevier
Abstract Both IL-17A and IL-22 share cellular sources and signaling pathways. They have
synergistic action on epithelial cells to stimulate their production of antimicrobial peptides …

[HTML][HTML] Network pharmacology and bioinformatics analysis identifies potential therapeutic targets of Naringenin against COVID-19/LUSC

W Wu, X Jiao, W Song, P Wu, P Xiao… - Frontiers in …, 2023 - frontiersin.org
Background Coronavirus disease 2019 (COVID‐19) is a highly contagious respiratory
disease that has posed a serious threat to people's daily lives and caused an …