Polysaccharides and their derivatives as potential antiviral molecules

H Claus-Desbonnet, E Nikly, V Nalbantova… - Viruses, 2022 - mdpi.com
In the current context of the COVID-19 pandemic, it appears that our scientific resources and
the medical community are not sufficiently developed to combat rapid viral spread all over …

Antivirals: past, present and future

E De Clercq - Biochemical pharmacology, 2013 - Elsevier
Vaccination is possible to prevent infections with some viruses: hepatitis B virus (HBV),
varicella-zoster virus (VZV), influenza A and B viruses, Yellow fever virus and poliovirus; but …

Antiviral activity of ribosome-inactivating proteins

L Citores, R Iglesias, JM Ferreras - Toxins, 2021 - mdpi.com
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2. 2.22)
that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs …

A 40-year journey in search of selective antiviral chemotherapy

E De Clercq - Annual review of pharmacology and toxicology, 2011 - annualreviews.org
My search for a selective antiviral chemotherapy started more than 40 years ago with
interferon inducers, then shifted to nucleoside analogs with the discovery of BVDU …

[PDF][PDF] Biologically important nucleosides: Modern trends in biotechnology and application

IA Mikhailopulo, AI Miroshnikov - Mendeleev Communications, 2011 - academia.edu
Mendeleev Communications Page 1 i VOLUME 21 NUMBER 2 2011 MENCEX (2) 57 – 114
(2011) Mendeleev Communications CONTENTS O X O P OH O O O B Y Z O X B1 Y Z – B1 O …

Highlights in the discovery of antiviral drugs: a personal retrospective

E De Clercq - Journal of medicinal chemistry, 2010 - ACS Publications
In 1959 Bill Prusoff described the synthesis of idoxuridine (5-iodo-2 0-deoxyuridine, IDUa), 1
later to become the first antiviral drug to be licensed for clinical use. This marked the birthday …

New trends in nucleoside biotechnology

IA Mikhailopulo, AI Miroshnikov - Acta Naturae (англоязычная …, 2010 - cyberleninka.ru
This review focuses on new trends in nucleoside biotechnology, which have emerged
during the last decade. Continuously growing interest in the study of this class of compounds …

[HTML][HTML] Fighting viruses with antibiotics: an overlooked path

P Colson, D Raoult - International journal of antimicrobial agents, 2016 - ncbi.nlm.nih.gov
Viruses are a serious threat for humans worldwide because there are in their ranks many
causative agents of potentially fatal infections and cancers [1, 2]. Despite this, emerging or re …

Mangiferin, an anti-HIV-1 agent targeting protease and effective against resistant strains

RR Wang, YD Gao, CH Ma, XJ Zhang, CG Huang… - Molecules, 2011 - mdpi.com
The anti-HIV-1 activity of mangiferin was evaluated. Mangiferin can inhibit HIV-1ⅢB induced
syncytium formation at non-cytotoxic concentrations, with a 50% effective concentration …

Benzimidazole nucleosides: Antiviral and antitumour activities and methods of synthesis

MI Kharitonova, ID Konstantinova… - Russian Chemical …, 2018 - iopscience.iop.org
The review systematically covers experimental data on the synthesis of modified
benzimidazole nucleosides and evaluation of their biological activity published mainly over …