Role of cytochrome P450 2C8 in drug metabolism and interactions
During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …
[HTML][HTML] Drug–drug interaction studies: regulatory guidance and an industry perspective
T Prueksaritanont, X Chu, C Gibson, D Cui, KL Yee… - The AAPS journal, 2013 - Springer
Recently, the US Food and Drug Administration and European Medicines Agency have
issued new guidance for industry on drug interaction studies, which outline comprehensive …
issued new guidance for industry on drug interaction studies, which outline comprehensive …
[HTML][HTML] Computational prediction of drug-drug interactions based on drugs functional similarities
Therapeutic activities of drugs are often influenced by co-administration of drugs that may
cause inevitable drug-drug interactions (DDIs) and inadvertent side effects. Prediction and …
cause inevitable drug-drug interactions (DDIs) and inadvertent side effects. Prediction and …
Coproporphyrins in plasma and urine can be appropriate clinical biomarkers to recapitulate drug-drug interactions mediated by organic anion transporting polypeptide …
Y Lai, S Mandlekar, H Shen, VK Holenarsipur… - … of Pharmacology and …, 2016 - ASPET
In the present study, an open-label, three-treatment, three-period clinical study of
rosuvastatin (RSV) and rifampicin (RIF) when administered alone and in combination was …
rosuvastatin (RSV) and rifampicin (RIF) when administered alone and in combination was …
Understanding the critical disposition pathways of statins to assess drug–drug interaction risk during drug development: it's not just about OATP1B1
R Elsby, C Hilgendorf, K Fenner - Clinical Pharmacology & …, 2012 - Wiley Online Library
The use of statins is widespread across disease areas because many patients have
comorbidities. Given that these drugs have become common as comedications, it is …
comorbidities. Given that these drugs have become common as comedications, it is …
[HTML][HTML] How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions
The risk assessment of organic anion transporting polypeptide (OATP) 1B1–mediated drug-
drug interactions (DDIs) is an indispensable part of drug development. We previously …
drug interactions (DDIs) is an indispensable part of drug development. We previously …
Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A
T Prueksaritanont, DA Tatosian, X Chu… - Clinical …, 2017 - Wiley Online Library
A microdose cocktail containing midazolam, dabigatran etexilate, pitavastatin, rosuvastatin,
and atorvastatin has been established to allow simultaneous assessment of a perpetrator …
and atorvastatin has been established to allow simultaneous assessment of a perpetrator …
Pitavastatin is a more sensitive and selective organic anion‐transporting polypeptide 1B clinical probe than rosuvastatin
T Prueksaritanont, X Chu, R Evers… - British journal of …, 2014 - Wiley Online Library
Aims Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic
anion‐transporting polypeptide (OATP) 1 B, but clinical data on their relative sensitivity and …
anion‐transporting polypeptide (OATP) 1 B, but clinical data on their relative sensitivity and …
[HTML][HTML] Regulation of organic anion transporting polypeptides (OATP) 1B1-and OATP1B3-mediated transport: an updated review in the context of OATP-mediated …
Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important hepatic
transporters that mediate the uptake of many clinically important drugs, including statins from …
transporters that mediate the uptake of many clinically important drugs, including statins from …