Dose‐dependent inhibition of OATP1B by rifampicin in healthy volunteers: comprehensive evaluation of candidate biomarkers and OATP1B probe drugs
D Mori, E Kimoto, B Rago, Y Kondo… - Clinical …, 2020 - Wiley Online Library
To address the most appropriate endogenous biomarker for drug–drug interaction risk
assessment, eight healthy subjects received an organic anion transporting polypeptide 1B …
assessment, eight healthy subjects received an organic anion transporting polypeptide 1B …
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 as important regulators of the pharmacokinetics of substrate drugs
K Maeda - Biological and Pharmaceutical Bulletin, 2015 - jstage.jst.go.jp
Nobody doubts the importance of organic anion transporting polypeptide (OATP) 1B1 and
1B3 in the clinical pharmacokinetics of substrate drugs. Based on the theory of …
1B3 in the clinical pharmacokinetics of substrate drugs. Based on the theory of …
Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
Z Shan, X Yang, H Liu, Y Yuan, Y Xiao, J Nan… - Cell Research, 2023 - nature.com
Members of the solute carrier organic anion transporting polypeptide (OATPs) family
function as transporters for a large variety of amphipathic organic anions including …
function as transporters for a large variety of amphipathic organic anions including …
The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so
A recent paper in this journal sought to counter evidence for the role of transport proteins in
effecting drug uptake into cells, and questions that transporters can recognize drug …
effecting drug uptake into cells, and questions that transporters can recognize drug …
Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction …
M Gertz, CM Cartwright, MJ Hobbs… - Pharmaceutical …, 2013 - Springer
Purpose To apply physiologically-based pharmacokinetic (PBPK) modeling to investigate
the consequences of reduction in activity of hepatic and intestinal uptake and efflux …
the consequences of reduction in activity of hepatic and intestinal uptake and efflux …
Transporter studies in drug development: experience to date and follow‐up on decision trees from the International Transporter Consortium
D Tweedie, JW Polli, EG Berglund… - Clinical …, 2013 - Wiley Online Library
The International Transporter Consortium (ITC) organized a second workshop in March
2012 to expand on the themes developed during the inaugural ITC workshop held in 2008 …
2012 to expand on the themes developed during the inaugural ITC workshop held in 2008 …
Physiologically‐based pharmacokinetic modeling‐guided dose management of oral anticoagulants when initiating nirmatrelvir/ritonavir (Paxlovid) for COVID‐19 …
Patients with coronavirus disease 2019 (COVID‐19) with cardiovascular diseases who are
at higher risk of progressing to critical illness should be treated with nirmatrelvir/ritonavir …
at higher risk of progressing to critical illness should be treated with nirmatrelvir/ritonavir …
Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions
A Vildhede, M Karlgren, EK Svedberg… - Drug metabolism and …, 2014 - ASPET
Differences in the expression and function of the organic anion transporting polypeptide
(OATP) transporters contribute to interindividual variability in atorvastatin clearance …
(OATP) transporters contribute to interindividual variability in atorvastatin clearance …
Coproporphyrins I and III as functional markers of OATP1B activity: in vitro and in vivo evaluation in preclinical species
H Shen, J Dai, T Liu, Y Cheng, W Chen… - … of Pharmacology and …, 2016 - ASPET
Inhibition of organic anion-transporting polypeptide (OATP) 1B function can lead to serious
clinical drug-drug interactions, thus a thorough evaluation of the potential for this type of …
clinical drug-drug interactions, thus a thorough evaluation of the potential for this type of …
Comparing various in vitro prediction criteria to assess the potential of a new molecular entity to inhibit organic anion transporting polypeptide 1B1
J Vaidyanathan, K Yoshida, V Arya… - The Journal of Clinical …, 2016 - Wiley Online Library
Abstract Evaluation of organic anion transporting polypeptide (OATP) 1B1–mediated drug‐
drug interactions (DDIs) is an integral part of drug development and is recommended by …
drug interactions (DDIs) is an integral part of drug development and is recommended by …