OBJECTIVE: Remitted major depressive disorder is a vulnerable clinical state, suggesting
persistence of an underlying disease diathesis between episodes. To investigate neural …

The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation
of mood, cognition and behavior and has been implicated in the pathophysiology of major …

BACKGROUND: There is growing evidence that individual differences among depressed
patients on electrophysiologic (EEG), neuroimaging, and neurocognitive measures are …

Many neurological disorders are accompanied by depression. Because the clinical
presentations of mood symptoms in neurological patients are similar to those seen in …

The goal of this review is to familiarize the reader about the potential involvement of the
brain reward system (BRS) in symptoms of Major Depressive Disorder (MDD). The authors …

Converging clinical, biochemical, postmortem, and neuroimaging evidence suggests that
depression is unlikely to be a disease of a single brain region or neurotransmitter system …

Reduced serotonergic activity has been associated with impulsive aggression in personality
disordered patients in metabolite and pharmacologic challenge studies. This study used …

OBJECTIVE: Sleep deprivation has been shown to have an antidepressant benefit in a
subgroup of depressed patients. Functional imaging studies by the authors and others have …

This volume provides a cutting-edge exposition to research on the self. Sixteen authoritative
overviews highlight the role of the self around four themes. The first theme is Brain and …

Functional brain imaging studies of subjects with Major Depressive Disorder (MDD) have
suggested that decreased dorsolateral (DLPFC) and increased ventrolateral (VLPFC) …