Bipolar disorder (BD) has been associated with abnormalities of brain structure. Specifically,
in vivo volumetric MRI and/or post mortem studies of BD have reported abnormalities of gray …

Background The Hamilton Depression Rating Scale (HDRS) is widely used to measure the
severity of depression in mood disorders. Total HDRS score correlates with brain …

The limbic system has consistently been associated with the control of emotions and with
mood disorders. The goal of this study was to identify new molecular targets associated with …

Objective: To examine the progress of positron emission tomography (PET) as a tool for
understanding the psychobiology of mood disorders, particularly major depression and …

Mood disorders are associated with regional brain abnormalities, including reductions in
glial cell and neuron number, glutamatergic irregularities, and differential patterns of brain …

Object. Neurosurgical procedures are a viable intervention for severe, treatment-refractory
major depression, although they have been associated with only modest rates of efficacy …

Background Serotonin reuptake inhibitors (SRIs) effectively treat both major depressive
disorder (MDD) and obsessive-compulsive disorder (OCD). We compared and contrasted …

Rationale Impulsive aggressive personality disordered patients have been shown to have
decreased relative glucose metabolism in orbito-frontal cortex and anterior cingulate gyrus …

Studies using diverse methods have documented frontostriatal and limbic dysfunction
occurring in late-life depression. Although such impairments may result from aging-induced …

Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may
contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This …