Obesity and cancer: Potential mediation by dysregulated dietary phosphate

RB Brown - Obesities, 2022 - mdpi.com
Next to smoking, obesity is the second leading preventable risk factor for cancer, but
increasing rates of obesity and overweight are estimated to overtake smoking as the leading …

The roles of sodium-independent inorganic phosphate transporters in inorganic phosphate homeostasis and in cancer and other diseases

MA Lacerda-Abreu, T Russo-Abrahão… - International Journal of …, 2020 - mdpi.com
Inorganic phosphate (Pi) is an essential nutrient for the maintenance of cells. In healthy
mammals, extracellular Pi is maintained within a narrow concentration range of 0.70 to 1.55 …

Inorganic phosphate (Pi) in the breast cancer microenvironment: Production, transport and signal transduction as potential targets for anticancer strategies

MA Lacerda-Abreu… - Current Cancer Drug …, 2023 - ingentaconnect.com
Tumor cells develop a high demand for inorganic phosphate (Pi) due to their high growth
rates and energy requirements. Serum Pi concentrations in cancer patients have been found …

[HTML][HTML] Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Z Wang, W Wang, A Yang, W Zhao, J Yang… - Journal of …, 2021 - ncbi.nlm.nih.gov
Population-based studies investigating the association between dietary mineral intake and
risk of cervical intraepithelial neoplasia (CIN) or cervical cancer in Chinese women are few …

Hydrogen peroxide generation as an underlying response to high extracellular inorganic phosphate (Pi) in breast cancer cells

MA Lacerda-Abreu, T Russo-Abrahão… - International Journal of …, 2021 - mdpi.com
According to the growth rate hypothesis (GRH), tumour cells have high inorganic phosphate
(Pi) demands due to accelerated proliferation. Compared to healthy individuals, cancer …

Elevated extracellular inorganic phosphate inhibits ecto‐phosphatase activity in breast cancer cells: Regulation by hydrogen peroxide

MA Lacerda‐Abreu… - Cell Biology …, 2024 - Wiley Online Library
For cells to obtain inorganic phosphate, ectoenzymes in the plasma membrane, which
contain a catalytic site facing the extracellular environment, hydrolyze phosphorylated …

Dysregulated phosphate metabolism, periodontal disease, and cancer: possible global health implications

RB Brown - Dentistry Journal, 2019 - mdpi.com
An association between periodontal disease and cancer has been established in recent
studies, but no common etiology has been identified in the hopes of reducing the global …

Is there any potential clinical impact of serum phosphorus and magnesium in patients with lung cancer at first diagnosis? A multi-institutional study

V Kouloulias, M Tolia, N Tsoukalas… - Asian Pacific Journal …, 2015 - koreascience.kr
Background: The aim of the study was to determine whether the expression of baseline
phosphorus (P) and magnesium (Mg) levels were prognostic in terms of stage and overall …

Potential interaction of inflammatory hyperemia and hyperphosphatemia in tumorigenesis

RB Brown - Future Oncology, 2019 - Taylor & Francis
The present article proposes that the association of inflammation with cancer is potentially
mediated by the interaction of inflammatory hyperemia and hyperphosphatemia. Hyperemia …

[HTML][HTML] Concentration study of high sensitive C-reactive protein and some serum trace elements in patients with benign and malignant breast tumor

A Abdollahi, A Ali-Bakhshi… - International journal of …, 2015 - ncbi.nlm.nih.gov
Background: Breast cancer is the most common invasive cancer in females worldwide. It
accounts for 16% of all female cancers and 22.9% of invasive cancers in women. 18.2% of …