Research Review: A guide to computing and implementing polygenic scores in developmental research

AG Allegrini, JR Baldwin, W Barkhuizen… - Journal of Child …, 2022 - Wiley Online Library
The increasing availability of genotype data in longitudinal population‐and family‐based
samples provides opportunities for using polygenic scores (PGS) to study developmental …

[HTML][HTML] Neuroimaging in attention-deficit/hyperactivity disorder

V Pereira-Sanchez, FX Castellanos - Current opinion in …, 2021 - journals.lww.com
Neuroimaging in attention-deficit/hyperactivity disorder : Current Opinion in Psychiatry
Neuroimaging in attention-deficit/hyperactivity disorder : Current Opinion in Psychiatry Log in or …

Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study

IMPACC Manuscript Writing Team… - Science …, 2021 - science.org
The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective
longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 …

An overview of DNA methylation-derived trait score methods and applications

MF Nabais, DA Gadd, E Hannon, J Mill, AF McRae… - Genome Biology, 2023 - Springer
Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …

Use of the PsycheMERGE network to investigate the association between depression polygenic scores and white blood cell count

JM Sealock, YH Lee, A Moscati, S Venkatesh… - JAMA …, 2021 - jamanetwork.com
Importance Although depression is a common psychiatric disorder, its underlying biological
basis remains poorly understood. Pairing depression polygenic scores with the results of …

Addressing the challenge of biomedical data inequality: An artificial intelligence perspective

Y Gao, T Sharma, Y Cui - Annual review of biomedical data …, 2023 - annualreviews.org
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …

Risk of early-onset depression associated with polygenic liability, parental psychiatric history, and socioeconomic status

E Agerbo, BB Trabjerg, AD Børglum, AJ Schork… - JAMA …, 2021 - jamanetwork.com
Importance Combining information on polygenic risk scores (PRSs) with other known risk
factors could potentially improve the identification of risk of depression in the general …

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study

N Kappelmann, D Czamara, N Rost, S Moser… - Brain, Behavior, and …, 2021 - Elsevier
Background About every fourth patient with major depressive disorder (MDD) shows
evidence of systemic inflammation. Previous studies have shown inflammation-depression …

Genetic contributions to anxiety disorders: where we are and where we are heading

H Ask, R Cheesman, ES Jami, DF Levey… - Psychological …, 2021 - cambridge.org
Anxiety disorders are among the most common psychiatric disorders worldwide. They often
onset early in life, with symptoms and consequences that can persist for decades. This …

Utility of polygenic embryo screening for disease depends on the selection strategy

T Lencz, D Backenroth, E Granot-Hershkovitz, A Green… - Elife, 2021 - elifesciences.org
Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization
embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of …