Polygenic scores in the direct-to-consumer setting: challenges and opportunities for a new era in consumer genetic testing

JK Park, CY Lu - Journal of Personalized Medicine, 2023 - mdpi.com
Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and
public intrigue. Although the current consumer genetic testing regime relies on the reporting …

How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID)

HL Kennedy, L Dinkler, MA Kennedy, CM Bulik… - Journal of Eating …, 2022 - Springer
Avoidant/restrictive food intake disorder (ARFID) was introduced in the fifth edition of the
Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Unlike anorexia nervosa …

Polygenic health index, general health, and pleiotropy: sibling analysis and disease risk reduction

E Widen, L Lello, TG Raben, LCAM Tellier, SDH Hsu - Scientific reports, 2022 - nature.com
We construct a polygenic health index as a weighted sum of polygenic risk scores for 20
major disease conditions, including, eg, coronary artery disease, type 1 and 2 diabetes …

Between nature and nurture: The genetic overlap between psychological attributes and selection into public service employment

L Tao, H Liang, B Wen, T Huang - Public Administration Review, 2023 - Wiley Online Library
Public administration scholars have had a long‐lasting interest in examining individual
differences relevant to the attractiveness of public service employment. However, very few …

Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood

A Neumann, A Jolicoeur‐Martineau… - Journal of Child …, 2022 - Wiley Online Library
Background Polygenic risk scores (PRSs) operationalize genetic propensity toward a
particular mental disorder and hold promise as early predictors of psychopathology, but …

Polygenic risk scores contribute to personalized medicine of Parkinson's disease

M Dehestani, H Liu, T Gasser - Journal of Personalized Medicine, 2021 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by the loss of dopaminergic neurons. The vast majority of PD patients develop …

[HTML][HTML] Predicting multiple sclerosis: Challenges and opportunities

L Hone, G Giovannoni, R Dobson… - Frontiers in Neurology, 2022 - frontiersin.org
Determining effective means of preventing Multiple Sclerosis (MS) relies on testing
preventive strategies in trial populations. However, because of the low incidence of MS …

Adolescent psychedelic use and psychotic or manic symptoms

O Simonsson, MA Mosing, W Osika, F Ullén… - JAMA …, 2024 - jamanetwork.com
Importance While psychedelic-assisted therapy has shown promise in the treatment of
certain psychiatric disorders, little is known about the potential risk of psychotic or manic …

Music and genetics

LW Wesseldijk, F Ullén, MA Mosing - Neuroscience & Biobehavioral …, 2023 - Elsevier
The first part of this review provides a brief historical background of behavior genetic
research and how twin and genotype data can be utilized to study genetic influences on …

The estimation of environmental and genetic parental influences

JV Balbona, Y Kim, MC Keller - Development and Psychopathology, 2022 - cambridge.org
Parents share half of their genes with their children, but they also share background social
factors and actively help shape their child's environment–making it difficult to disentangle …