We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to
investigate sibling variation in both phenotype and genotype. We compare phenotype …

Although still in the early stages of development, the advent of fast, high-output, and cost-
effective next-generation DNA sequencing technology is moving precision medicine into …

Crohn's disease (CD) is a type of inflammatory bowel disease. The number of IBD cases
worldwide was estimated to be 4.9 million in 2019. CD exhibits heterogeneity in clinical …

It remains inconclusive whether postpartum depression (PPD) and depression with onset
outside the postpartum period (MDD) are genetically distinct disorders. We aimed to …

The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …

BACKGROUND The genetic composition of embryos generated by in vitro fertilization (IVF)
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …

The present study illustrates the utility of latent class analysis, a person‐centered data
analytic approach, as an innovative method for identifying naturally occurring patterns of …

Little is known regarding the polygenic underpinnings of anomalous resting-state functional
connectivity (rsFC) in youth bipolar disorder (BD). The current study examined the …

The development of genome-informed methods for identifying quantitative trait loci (QTL)
and studying the genetic basis of quantitative variation in natural and experimental …

Background We used a polygenic score for externalizing behavior (extPGS) and structural
MRI to examine potential pathways from genetic liability to conduct problems via the brain …