Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations

L Kausel, A Figueroa-Vargas, F Zamorano… - Scientific Reports, 2024 - nature.com
Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the
specific neuropathological mechanisms and risk factors underlying these alterations remain …

Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations

C Marin, I Alobid, M López-Chacón… - Current Allergy and …, 2024 - Springer
Abstract Purpose of Review Neurogenesis occurring in the olfactory epithelium is critical to
continuously replace olfactory neurons to maintain olfactory function, but is impaired during …

Inflammatory response and defects on myelin integrity in the olfactory system of K18hACE2 mice infected with SARS-CoV-2

E Martin-Lopez, B Brennan, T Mao, N Spence… - eneuro, 2024 - eneuro.org
Viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), use
respiratory epithelial cells as an entry point for infection. Within the nasal cavity, the olfactory …

Transcriptome from paired samples improves the power of comprehensive COVID-19 host-viral characterization

O Milicevic, A Loncar, D Abazovic, M Vukcevic… - International Journal of …, 2023 - mdpi.com
Previous transcriptome profiling studies showed significantly upregulated genes and altered
biological pathways in acute COVID-19. However, changes in the transcriptional signatures …

Potential contribution of cell adhesion molecule 1 to the binding of SARS-CoV-2 spike protein to mouse nasal mucosa

F Takeuchi, A Sugano, A Yoneshige, M Hagiyama… - Cells Tissues …, 2023 - karger.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first infects the host nasal
mucosa, where the viral spike protein binds to angiotensin-converting enzyme 2 (ACE2) on …

Histochemical Evidence for Reduced Immune Response in Nasal Mucosa of Patients with COVID-19

N Power Guerra, M Bierkämper, J Pablik… - International Journal of …, 2024 - mdpi.com
The primary entry point of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is the nasal mucosa, where viral-induced inflammation occurs. When the immune response …

[HTML][HTML] Maximizing Participation in Olfactory Training in a Sample with Post-COVID-19 Olfactory Loss

AH Delgado-Lima, J Bouhaben, ML Delgado-Losada - Brain Sciences, 2024 - mdpi.com
Purpose: This study aims to highlight the feasibility of an olfactory training program entirely
monitored through online media in COVID-19 patients. Methods: Classic olfactory training …

[HTML][HTML] Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects

NN Al-Saigh, AA Harb, S Abdalla - International Journal of Molecular …, 2024 - mdpi.com
Olfactory perception is an important physiological function for human well-being and health.
Loss of olfaction, or anosmia, caused by viral infections such as severe acute respiratory …

[HTML][HTML] Cytoskeletal β-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y

BR Oliveira, I Nehlmeier, AM Kempf, V Venugopalan… - Biochimie, 2024 - Elsevier
SARS-CoV-2 mainly infects the respiratory tract but can also target other organs, including
the central nervous system. While it was recently shown that cells of the blood-brain-barrier …

Pro‐inflammatory markers associated with COVID‐19‐related persistent olfactory dysfunction

SS Jang, KS Pak, A Strom, L Gomez… - International forum of …, 2024 - Wiley Online Library
Introduction While localized inflammation has been implicated in the pathophysiology of
acute coronavirus disease of 2019 (COVID‐19) olfactory dysfunction (OD), persistent COVID …