Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation
M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …
cancer. Developments in protein engineering and materials science have led to the …
Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
E Kon, N Ad-El, I Hazan-Halevy… - Nature Reviews …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …
ongoing research area that started before these versatile nanoparticles were successfully …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
[HTML][HTML] Polymeric micellar systems—A special emphasis on “smart” drug delivery
Concurrent developments in anticancer nanotechnological treatments have been observed
as the burden of cancer increases every year. The 21st century has seen a transformation in …
as the burden of cancer increases every year. The 21st century has seen a transformation in …
Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy
Y Guo, Q Bao, P Hu, J Shi - Nature Communications, 2023 - nature.com
Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy.
Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral …
Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral …
The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles
Messenger RNA (mRNA) can treat genetic disease using protein replacement or genome
editing approaches but requires a suitable carrier to circumnavigate biological barriers and …
editing approaches but requires a suitable carrier to circumnavigate biological barriers and …
Self-Amplified Cascade Degradation and Oxidative Stress Via Rational pH Regulation of Oxidation-Responsive Poly (ferrocene) Aggregates
C Song, M Chen, J Tan, J Xu, Y Zhang… - Journal of the …, 2023 - ACS Publications
Precise activation of polymer nanoparticles at lesion sites is crucial to achieve favorable
therapeutic efficacy. However, conventional endogenous stimuli-responsive polymer …
therapeutic efficacy. However, conventional endogenous stimuli-responsive polymer …
Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …