Importance To date, recurrent implantation failure (RIF) has no clear definition and no clearly
identified impaired function. Hence, the term RIF is currently used somewhat haphazardly …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The
prevalence of these abnormalities and the allocation of (ab) normal cells in embryonic and …

Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of
how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel …

Recent advances highlight the pivotal role of nicotinamide adenine dinucleotide (NAD+) in
ovarian aging. However, the roles of de novo NAD+ biosynthesis on ovarian aging are still …

Chromosome segregation errors in mammalian oocyte meiosis lead to developmentally
compromised aneuploid embryos and become more common with advancing maternal age …

The ovarian microenvironment becomes fibrotic and stiff with age, in part due to increased
collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex …

Background With advanced maternal age, abnormalities during oocyte meiosis increase
significantly. Aneuploidy is an important reason for the reduction in the quality of aged …

Single-cell whole-genome sequencing methods have undergone great improvements over
the past decade. However, allele dropout, which means the inability to detect both alleles …