Mammalian preimplantation embryos often contend with aneuploidy that arose either by the
inheritance of meiotic errors from the gametes, or from mitotic mis-segregation events that …

The decline in female fertility as age advances is intricately linked to the diminished
developmental potential of oocytes. Despite this challenge, the strategies available to …

In dividing cells, accurate chromosome segregation depends on sister chromatid cohesion,
protein linkages that are established during DNA replication. Faithful chromosome …

Human oocyte maturation arrest represents one of the severe conditions for female patients
with primary infertility. However, the genetic factors underlying this human disease remain …

Determining egg quality is the foremost challenge in assisted reproductive technology
(ART). Although extensive advances have been made in multiple areas of ART over the last …

Abstract Sirtuin 5 (Sirt5), a member of the Sirtuin family, is involved in various intracellular
biological processes. However, the function of Sirt5 in oocyte maturation has not been …

In the first weeks after fertilization, embryo mortality in cattle is significantly higher. It is well
known that the age of the dam is one of the crucial factors affecting the quality of embryos …

Aneuploidy is one of the main causes of miscarriage and in vitro fertilization failure. Mitotic
abnormalities in preimplantation embryos are the main cause of mosaicism, which may be …

Klinefelter syndrome (KS) is the most prevalent chromosomal disorder occurring in males. It
is defined by an additional X chromosome, 47, XXY, resulting from errors in chromosomal …

Control mechanisms of spindle assembly and chromosome segregation are vital for
preventing aneuploidy during cell division. The mammalian germ cells and embryos are …