An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations
Inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main
protease (Mpro) such as nirmatrelvir (NTV) and ensitrelvir (ETV) have proven effective in …
protease (Mpro) such as nirmatrelvir (NTV) and ensitrelvir (ETV) have proven effective in …
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and related variants, are
responsible for the devastating coronavirus disease 2019 (COVID-19) pandemic. The SARS …
responsible for the devastating coronavirus disease 2019 (COVID-19) pandemic. The SARS …
[HTML][HTML] Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity
DW Carney, AE Leffler, JA Bell… - Bioorganic & Medicinal …, 2024 - Elsevier
Small-molecule antivirals that prevent the replication of the SARS-CoV-2 virus by blocking
the enzymatic activity of its main protease (Mpro) are and will be a tenet of pandemic …
the enzymatic activity of its main protease (Mpro) are and will be a tenet of pandemic …
The Value of Ursodeoxycholic Acid and Mesenchymal Stem Cells in the Treatment of Severe COVID-19
Q Zheng, Y Li, G Sheng, L Li - Microorganisms, 2024 - mdpi.com
Objective: The objective of this study was to evaluate the therapeutic efficacy of
ursodeoxycholic acid (UDCA) and mesenchymal stem cells (MSCs) in patients with severe …
ursodeoxycholic acid (UDCA) and mesenchymal stem cells (MSCs) in patients with severe …
A Computational Comparison Between Pomotrelvir and Nirmatrelvir Binding and Reactivity with SARS-CoV-2 Main Protease. Implications for Resistance Mechanisms
J Schillings, CA Ramos-Guzmán, JJ Ruiz-Pernía… - 2024 - chemrxiv.org
This study investigates the binding mode and reaction mechanism between pomotrelvir and
the SARS-CoV-2 main protease using a combination of molecular mechanics and hybrid …
the SARS-CoV-2 main protease using a combination of molecular mechanics and hybrid …
Coronavirus (CoV) proteins in GtoPdb v. 2023.3
Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA
viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly …
viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly …