The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …

Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Abstract Deciphering Multiple Myeloma evolution in the whole bone marrow is key to inform
curative strategies. Here, we perform spatial-longitudinal whole-exome sequencing …

Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system
and exhibits diverse patterns of metastasis without systematical genomic investigation. Here …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …

In cancer, evolutionary forces select for clones that evade the immune system. Here we
analyzed> 10,000 primary tumors and 356 immune-checkpoint-treated metastases using …

Somatic genetic variation (SoGV) may play a consequential yet underappreciated role in
long-lived, modular species among plants, animals, and fungi. Recent genomic data …

With the completion of the International Human Genome Project, we have entered what is
known as the post-genome era, and efforts to apply genomic information to medicine have …

Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer (GC) that
histologically resembles hepatocellular carcinoma (HCC). Despite its low incidence, HAS …