Fibrosis is the extensive deposition of fibrous connective tissue, and it is characterized by
the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is …

Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of
malignant plasma cells nurtured within a permissive bone marrow microenvironment. While …

Abstract Background Circular RNAs (circRNAs) represent a class of non-coding RNAs
(ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could …

Abstract Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-
inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Coeliac disease is a common small bowel enteropathy arising in genetically predisposed
individuals and caused by ingestion of gluten in the diet. Great advances have been made …

Inflammasomes are cytosolic polyprotein complexes formed in response to various external
and internal stimuli, including viral and bacterial antigens. The main product of the …

Obesity is a growing epidemic worldwide, and it is also considered a major environmental
factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis …

Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult
tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early stage …