Acute graft-versus-host disease (aGVHD) is a severe T cell-mediated immune response
after allogeneic hematopoietic stem cell transplantation (allo-HSCT), the molecular …

The pathophysiology of CRS is multifactorial and complex yet needs to be completed.
Recent evidence emphasizes the crucial part played by epithelial cells in the development …

Idiopathic pulmonary fibrosis (IPF) is a chronic and refractory interstitial lung disease.
Although there is no cure for IPF, the development of drugs with improved efficacy in the …

Chronic obstructive pulmonary disease (COPD) is a complex disease with multiple
etiologies, while smoking is the most established one. The present study investigated the …

Abstract Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a
number of immune cells involved in the immune microenvironment of the body. IL-22 plays …

Background: This study investigates the therapeutic and protective effects of Tregs, myeloid-
derived suppressor cells (MDSCs) and IL-2 on multiple sclerosis (MS) disease model …

With the incidence of hypertension increasing worldwide, more and more the mechanisms of
hypertension from the perspective of immunity have found. Intestinal microbiota as well as its …

Both acute and chronic kidney disease have a strong underlying inflammatory component.
This review focuses primarily on T helper 17 (Th17) cells as mediators of inflammation and …

Objectives The human leucocyte antigen (HLA)-B27 confers an increased risk of
spondyloarthritis (SpA) by unknown mechanism. The objective of this work was to uncover …

Inflammasome molecules make up a family of receptors that typically function to initiate a
proinflammatory response upon infection by microbial pathogens. Dysregulation of …