Increasing endogenous tear film production via pharmacological neuroactivation of the
nasolacrimal reflex [NLR; also known as the trigeminal parasympathetic pathway (TPP)] is a …

Introduction Dry eye disease (DED) is a common ocular condition with a significant impact
on patients' quality of life. Conventional treatments include behavioral changes, tear …

Tear secretion is regulated by the lacrimal functional unit consisting of afferent and efferent
nerve innervation. The afferent arm consists of trigeminal nociceptors on the ocular surface …

Although the ultimate goal of dry eye disease (DED) management is to restore the ocular
surface and tear film homeostasis and address any accompanying symptoms, addressing …

Background Dry eye disease (DED) is caused by a persistently unstable tear film leading to
ocular discomfort and is treated mainly with tear supplementation. There is emerging …

Aim: Herein, we report safety outcomes for varenicline solution nasal spray (VNS) within the
context of clinical trial discontinuation, contrasting those with discontinuation outcomes from …

Introduction This study sought to compare the efficacy of OC-01 (varenicline solution) nasal
spray for treatment of dry eye disease (DED) in postmenopausal women (PM+) versus …

Purpose This study compares outcomes of therapy with OC-01 (varenicline solution) for dry
eye disease in study eyes and nonstudy fellow eyes of participants in 2 pivotal clinical trials …

Purpose We evaluate the treatment effect of OC-01 (varenicline solution) nasal spray (VNS)
in dry eye disease (DED) subjects from two randomized trials who self-reported autoimmune …

The aim of this paper is to evaluate the efficacy and safety of Rebamipide (REB) ophthalmic
suspension in dry eye disease (DED). A systematic review that only included full-length …