Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

The biological complexity of cancer represents a tremendous clinical challenge, resulting in
the frequent failure of current treatment protocols. In the rapidly evolving scenario of a …

Precancerous lesions of the oral mucosa, especially those accompanied by moderate to
severe dysplasia, contribute to the initiation of oral squamous cell carcinoma (OSCC) …

Personalized treatment strategies for cancer frequently rely on the detection of genetic
alterations which are determined by molecular biology assays. Historically, these processes …

The application of nanomaterials in healthcare has emerged as a promising strategy due to
their unique structural diversity, surface properties, and compositional diversity. In particular …

Acquired drug resistance is a major challenge for cancer therapy and is the leading cause of
cancer mortality; however, the mechanisms of drug resistance are diverse and the strategy …

viii everybody who contributed to the first edition. As always, I have to thank my wife and
family for encouragement and support (as well as patience…). I hope you will find this book …

Abstract Background Immune checkpoint inhibitors (ICIs) have demonstrated promising
outcomes in small cell lung cancer (SCLC), but not all patients benefit from it. Thus …

The continuing evolution of treatment options in thoracic oncology requires the pathologist to
regularly update diagnostic algorithms for management of tumor samples. It is essential to …

The β− emitter, rhenium-188 (188Re), has long been recognized as an attractive candidate
for targeted cancer radionuclide therapy (TRNT). This transition metal shares chemical …