Background Biallelic PRKN mutation carriers with Parkinson's disease (PD) typically have
an earlier disease onset, slow disease progression, and, often, different neuropathology …

Background Molecules related to glucocerebrosidase (GCase) are potential biomarkers for
development of compounds targeting GBA1‐associated Parkinson's disease (GBA‐PD) …

Genome-wide association studies (GWAS) have identified numerous loci associated with
Parkinson's disease. The specific genes and variants that drive the associations within the …

Background: Both genetic and environmental factors contribute to Parkinson's disease (PD)
risk. Objective: We investigated the potential association of several relevant variables with …

Background Loss‐of‐function mutations in the GBA1 gene are one of the most common
genetic risk factors for onset of Parkinson's disease and subsequent progression (GBA‐PD) …

Background GBA variants are the most common genetic risk factors for Parkinson's disease
(PD) world-wide, and can be found in up to 20% of Ashkenazi PD patients. The E326K …

Gaucher disease (GD) is a rare autosomal recessive lysosomal storage disorder caused by
pathologic variants in GBA1, the gene encoding the enzyme glucocerebrosidase. Deficiency …

Background Mutations in the glucocerebrosidase (GBA) gene are strongly associated with
REM sleep behavior disorder (RBD). It is unclear whether GBA mutations might affect …

Parkinson's disease (PD) is characterized by gradual neurodegeneration and forfeiture of
dopamine neurons in substantia nigra pars compacta which ultimately leads to depletion of …

Background: Glucocerebrosidase (GBA) gene mutations and APOE polymorphisms are
common in dementia with Lewy bodies (DLB), however their clinical impact is only partially …