The morphologic properties of brain regions co-vary or correlate with each other. Here we
investigated the structural covariances of cortical thickness and subcortical volumes in the …

In older adults, changes in brain structure can be used to identify and predict the risk of
neurodegenerative disorders and dementias. Traditional 'brainAge'methods seek to identify …

Alzheimer Disease (AD) is a highly polygenic disease that presents with relatively earlier
onset (≤ 70yo; EOAD) in about 5% of cases. Around 90% of these EOAD cases remain …

Modern brain-wide transcriptional atlases provide unprecedented opportunities for
investigating the molecular correlates of brain organization, as quantified using non-invasive …

Compared with our fossil ancestors and Neandertal kin, modern humans have evolved a
distinctive skull shape, with a rounder braincase and more delicate face. Competing …

Across healthy adult life our brains undergo gradual structural change in a pattern of atrophy
that resembles accelerated brain changes in Alzheimer's disease (AD). Here, using four …

Neuroimaging has provided important insights into the brain variations related to mental
illness. Inconsistencies in prior studies, however, call for methods that lead to more …

Age-related brain disorders are a group of conditions characterised by the progressive loss
of structure and function of neurons in the brain. These disorders primarily affect older …

Spatially heterogeneous synapse loss is a characteristic of many psychiatric and
neurological disorders, but the underlying mechanisms are unclear. Here, we show that …

The influence of genetic predisposition on changes in brain morphology during aging
remains largely unknown. This study explores the effects of genetic predisposition on three …