Disrupted calcium homeostasis in duchenne muscular dystrophy: A common mechanism behind diverse consequences

B Zabłocka, DC Górecki, K Zabłocki - International Journal of Molecular …, 2021 - mdpi.com
Duchenne muscular dystrophy (DMD) leads to disability and death in young men. This
disease is caused by mutations in the DMD gene encoding diverse isoforms of dystrophin …

The dystrophin node as integrator of cytoskeletal organization, lateral force transmission, fiber stability and cellular signaling in skeletal muscle

P Dowling, S Gargan, S Murphy, M Zweyer, H Sabir… - Proteomes, 2021 - mdpi.com
The systematic bioanalytical characterization of the protein product of the DMD gene, which
is defective in the pediatric disorder Duchenne muscular dystrophy, led to the discovery of …

Mass spectrometry‐based proteomics approaches to interrogate skeletal muscle adaptations to exercise

DT Cervone, R Moreno‐Justicia… - … Journal of Medicine …, 2024 - Wiley Online Library
Acute exercise and chronic exercise training elicit beneficial whole‐body changes in
physiology that ultimately depend on profound alterations to the dynamics of tissue‐specific …

Mass spectrometry-based proteomic technology and its application to study skeletal muscle cell biology

P Dowling, D Swandulla, K Ohlendieck - Cells, 2023 - mdpi.com
Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …

Histopathology of Duchenne muscular dystrophy in correlation with changes in proteomic biomarkers

M Zweyer, H Sabir, P Dowling, S Gargan, S Murphy… - 2022 - digitum.um.es
Duchenne muscular dystrophy is an inherited disorder of early childhood that affects
multiple systems in the body. Besides late-onset cardio-respiratory syndrome and various …

Proteomic analysis of the sarcolemma-enriched fraction from dystrophic mdx-4cv skeletal muscle

S Murphy, M Zweyer, M Henry, P Meleady… - Journal of …, 2019 - Elsevier
The highly progressive neuromuscular disorder dystrophinopathy is triggered by primary
abnormalities in the Dmd gene, which causes cytoskeletal instability and loss of …

Emerging proteomic biomarkers of X-linked muscular dystrophy

P Dowling, S Murphy, M Zweyer… - Expert Review of …, 2019 - Taylor & Francis
Introduction: Progressive skeletal muscle wasting is the manifesting symptom of Duchenne
muscular dystrophy, an X-linked inherited disorder triggered by primary abnormalities in the …

Proteomic profiling of impaired excitation–contraction coupling and abnormal calcium handling in muscular dystrophy

P Dowling, S Gargan, D Swandulla, K Ohlendieck - Proteomics, 2022 - Wiley Online Library
The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is
characterised by primary abnormalities in the membrane cytoskeletal component dystrophin …

Comparative gel‐based proteomic analysis of chemically crosslinked complexes in dystrophic skeletal muscle

S Murphy, M Zweyer, RR Mundegar… - …, 2018 - Wiley Online Library
Duchenne muscular dystrophy is a highly progressive muscle wasting disease with a
complex pathophysiology that is based on primary abnormalities in the dystrophin gene. In …

[HTML][HTML] Proteomic identification of elevated saliva kallikrein levels in the mdx-4cv mouse model of Duchenne muscular dystrophy

S Murphy, M Zweyer, RR Mundegar… - … and Biophysics Reports, 2019 - Elsevier
Dystrophinopathies are multi-system disorders that affect the skeletal musculature, the
cardio-respiratory system and the central nervous system. The systematic screening of …