Prevalence of clinical trial status discrepancies: A cross-sectional study of 10,492 trials registered on both ClinicalTrials. gov and the European Union Clinical Trials …

J Fleminger, B Goldacre - PLoS One, 2018 - journals.plos.org
Objective Trial registries are a key source of information for clinicians and researchers.
While building OpenTrials, an open database of public trial information, we identified errors …

[HTML][HTML] Prototypical clinical trial registry based on fast healthcare interoperability resources (FHIR): design and implementation study

C Gulden, R Blasini, A Nassirian, A Stein… - JMIR medical …, 2021 - medinform.jmir.org
Background: Clinical trial registries increase transparency in medical research by making
information and results of planned, ongoing, and completed studies publicly available …

Challenges of identifying unpublished data from clinical trials: getting the best out of clinical trials registers and other novel sources

J Isojarvi, H Wood, C Lefebvre… - Research synthesis …, 2018 - Wiley Online Library
Clinical trial data are essential for assessments of the effectiveness of health care
interventions. Information about ongoing or completed, but not yet formally published, trials …

Big data in nephrology

N Kaur, S Bhattacharya, AJ Butte - Nature Reviews Nephrology, 2021 - nature.com
A huge array of data in nephrology is collected through patient registries, large
epidemiological studies, electronic health records, administrative claims, clinical trial …

Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods

P Créquit, I Boutron, J Meerpohl, HC Williams… - Journal of clinical …, 2020 - Elsevier
To become user driven and more useful for decision-making, the current evidence synthesis
ecosystem requires significant changes (Paper 1. Future of evidence ecosystem series) …

Design and implementation of medical searching system based on microservices and serverless architectures

J Sadek, D Craig, M Trenell - Procedia Computer Science, 2022 - Elsevier
Microservices and Serverless computing are promising cloud-based architectural models in
the software development industry that have many advantages over previous technology …

A metadata schema for data objects in clinical research

S Canham, C Ohmann - Trials, 2016 - Springer
Background A large number of stakeholders have accepted the need for greater
transparency in clinical research and, in the context of various initiatives and systems, have …

Why Cochrane should prioritise sharing data

F Shokraneh, CE Adams, M Clarke, L Amato, H Bastian… - Bmj, 2018 - bmj.com
Packer 1 says that the one who submits a research for public good should be ready to
receive a request for data sharing for examination and re-analysis and that tax payers …

[PDF][PDF] Fail fast, fail forward, fail openly: the need to share failures in development

RC Sindall, DJ Barrington - Journal of Trial & Error, 2020 - assets.pubpub.org
Failure is an integral part of learning: The adage “If at first you don't succeed, try, try, try
again” was originally coined to encourage children to persevere with their school work …

Standards for design and measurement would make clinical research reproducible and usable

K Dickersin, E Mayo-Wilson - Proceedings of the National …, 2018 - National Acad Sciences
We find standards useful in everyday life and in science, although we do not always follow
them. Adopting new standards can be expensive, so there may be a strong incentive to …