Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells

C Lu, J Wu, H Wang, S Wang, N Diao, F Wang, Y Gao… - PloS one, 2011 - journals.plos.org
Background Humans infected with Mycobacterium tuberculosis (MTB) can delete the
pathogen or otherwise become latent infection or active disease. However, the factors …

Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells

SG Crich, M Cadenazzi, S Lanzardo, L Conti, R Ruiu… - Nanoscale, 2015 - pubs.rsc.org
In this work the selective uptake of native horse spleen ferritin and apoferritin loaded with
MRI contrast agents has been assessed in human breast cancer cells (MCF-7 and MDA-MB …

Functional genomic studies: insights into the pathogenesis of liver cancer

ZG Han - Annual review of genomics and human genetics, 2012 - annualreviews.org
Liver cancer is the sixth-most-common cancer overall but the third-most-frequent cause of
cancer death. Among primary liver cancers, hepatocellular carcinoma (HCC), the major …

SPAG5 promotes hepatocellular carcinoma progression by downregulating SCARA5 through modifying β-catenin degradation

H Liu, J Hu, R Wei, L Zhou, H Pan, H Zhu… - Journal of Experimental …, 2018 - Springer
Background The sperm-associated antigen 5 (SPAG5) plays a key role in controlling various
cellular phenomena, including cell cycle progression and proliferation. However, the role of …

Suppression of SCARA5 by Snail1 is essential for EMT-associated cell migration of A549 cells

J Liu, G Hu, D Chen, AY Gong, GS Soori, TJ Dobleman… - Oncogenesis, 2013 - nature.com
Accumulating evidence indicates that epithelial-to-mesenchymal transition (EMT) might be a
key event for cancer progression. The upregulation of Snail1, one of the most extensively …

Protein cage nanostructure as drug delivery system: magnifying glass on apoferritin

D Belletti, F Pederzoli, F Forni, MA Vandelli… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: New frontiers in nanomedicine are moving towards the research of new
biomaterials. Apoferritin (APO), is a uniform regular self-assemblies nano-sized protein with …

Epigenetic therapy as a novel approach in hepatocellular carcinoma

I Anestopoulos, GP Voulgaridou… - Pharmacology & …, 2015 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of liver malignancy and one with
high fatality. Its 5-year survival rate remains low and thus, there is a need for improvement of …

Carcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5 …

Y Han, X Qian, T Xu, Y Shi - Cancer Biology & Therapy, 2022 - Taylor & Francis
ABSTRACT microRNA-331-3p (miR-331-3p) has been displayed as an oncogene in
pancreatic cancer (PC). The current research set out to elucidate how miR-331-3p in …

Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma

N Cheng, Y Li, ZG Han - Hepatology, 2013 - journals.lww.com
Hepatocellular carcinoma (HCC) is one of the most common cancers and shows a
propensity to metastasize and infiltrate adjacent and more distant tissues. However, the …

SCARA5 plays a critical role in the progression and metastasis of breast cancer by inactivating the ERK1/2, STAT3, and AKT signaling pathways

K You, F Su, L Liu, X Lv, J Zhang, Y Zhang… - Molecular and Cellular …, 2017 - Springer
Scavenger receptor class A member 5 (SCARA5) is a candidate anti-oncogene in several
malignancies. However, whether SCARA5 is a suppressor gene in breast cancer and its role …