Chimeric rodent malaria parasites with the endogenous circumsporozoite protein (csp) gene
replaced with csp from the human parasites Plasmodium falciparum (Pf) and P. vivax (Pv) …

Introduction Pre-erythrocytic malaria vaccines hold the promise of inducing sterile protection
thereby preventing the morbidity and mortality associated with Plasmodium infection. The …

Background New strategies are needed to reduce the incidence of malaria, and promising
approaches include the development of vaccines and monoclonal antibodies (mAbs) that …

Plasmodium sporozoites express circumsporozoite protein (CSP) on their surface, an
essential protein that contains central repeating motifs. Antibodies targeting this region can …

Malaria is one of the most dangerous infectious diseases in the world. It occurs in tropical
and subtropical regions and affects about 40% of the world´ s population. In endemic …

Abstract Background World Health Organization recommend the use of malaria vaccine,
Mosquirix, as a malaria prevention strategy. However, Mosquirix has failed to reduce the …

The monoclonal antibody CIS43 targets the Plasmodium falciparum circumsporozoite
protein (PfCSP) and prevents malaria infection in humans for up to 9 mo following a single …

The generation of high-quality antibody responses to PfCSP, the primary surface antigen of
Plasmodium falciparum sporozoites, is paramount to the development of an effective malaria …

Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs)
using prime-boost regimens with HIV envelope (Env) immunogens. Early antibody …

Malaria infects millions of people every year, and despite recent advances in controlling
disease spread, such as vaccination, it remains a global health concern. The …