Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from Plasmodium Infection in a Murine …
Malaria infects millions of people every year, and despite recent advances in controlling
disease spread, such as vaccination, it remains a global health concern. The …
disease spread, such as vaccination, it remains a global health concern. The …
[PDF][PDF] An antibody drug engineered for prevention of malaria in global populations
K Williams, S Guerrero, Y Flores-Garcia, K Andrews… - Res. Sq, 2023 - ketchem.net
Over 80% of malaria-attributable deaths are in children under ve. However, the only malaria
vaccine recommended by the World Health Organization (WHO) for paediatric use …
vaccine recommended by the World Health Organization (WHO) for paediatric use …
Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2
The utilization of avidity to drive and tune functional responses is fundamental to antibody
biology and often underlies the mechanisms of action of monoclonal antibody drugs. There …
biology and often underlies the mechanisms of action of monoclonal antibody drugs. There …
Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats
A Amen, R Yoo, A Fabra-García, J Bolscher… - bioRxiv, 2023 - biorxiv.org
Circulating sexual stages of Plasmodium falciparum (Pf) can be transmitted from humans to
mosquitoes, thereby furthering the spread of malaria in the population. It is well established …
mosquitoes, thereby furthering the spread of malaria in the population. It is well established …
In Silico Improvement of Highly Protective Anti-Malarial Antibodies
M Reveiz, P Tripathi, L Da Silva Pereira, P Kiyuka… - bioRxiv, 2022 - biorxiv.org
Antibody CIS43 binds Plasmodium falciparum circumsporozoite protein (PfCSP) and
protects against malaria, as recently demonstrated clinically. To improve the efficacy of …
protects against malaria, as recently demonstrated clinically. To improve the efficacy of …
High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire
Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite
protein (PfCSP) can prevent infection and disease. PfCSP contains multiple central …
protein (PfCSP) can prevent infection and disease. PfCSP contains multiple central …
Malaria-Antigene in der Ära der mRNA-Impfstoffe
Y Borkens - Monatsschrift Kinderheilkunde, 2022 - Springer
Bereits in den frühen 1990er-Jahren wurde erstmals eine durch einen mRNA-Impfstoff
ausgelöste Immunantwort beschrieben. Seitdem wurden mRNA-Impfstoffe für eine mögliche …
ausgelöste Immunantwort beschrieben. Seitdem wurden mRNA-Impfstoffe für eine mögliche …
Antibody complexes
RR Akhouri, LG Öfverstedt, G Wilken… - … Protein Complexes II …, 2019 - Springer
Monoclonal based therapeutics have always been looked at as a futuristic natural way we
could take care of pathogens and many diseases. However, in order to develop, establish …
could take care of pathogens and many diseases. However, in order to develop, establish …
[HTML][HTML] Malaria-Antigene in der Ära der mRNA-Impfstoffe: Mögliche Rettungen vor einer der relevantesten und gefährlichsten Kinderkrankheiten des Globalen …
Y Borkens - Monatsschrift Kinderheilkunde, 2022 - ncbi.nlm.nih.gov
Bereits in den frühen 1990er-Jahren wurde erstmals eine durch einen mRNA-Impfstoff
ausgelöste Immunantwort beschrieben. Seitdem wurden mRNA-Impfstoffe für eine mögliche …
ausgelöste Immunantwort beschrieben. Seitdem wurden mRNA-Impfstoffe für eine mögliche …
Isolation and characterization of human monoclonal antibodies blocking Plasmodium falciparum transmission
A Amen - 2022 - theses.hal.science
Among people naturally exposed to Plasmodium falciparum (Pf) in endemic areas some
naturally develop antibodies that are capable of inhibiting the development of the parasites …
naturally develop antibodies that are capable of inhibiting the development of the parasites …