Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

[HTML][HTML] Therapeutic potential of vagus nerve stimulation for inflammatory bowel diseases

B Bonaz, V Sinniger, S Pellissier - Frontiers in neuroscience, 2021 - frontiersin.org
The vagus nerve is a mixed nerve, comprising 80% afferent fibers and 20% efferent fibers. It
allows a bidirectional communication between the central nervous system and the digestive …

INFOGEST static in vitro simulation of gastrointestinal food digestion

A Brodkorb, L Egger, M Alminger, P Alvito… - Nature protocols, 2019 - nature.com
Developing a mechanistic understanding of the impact of food structure and composition on
human health has increasingly involved simulating digestion in the upper gastrointestinal …

[HTML][HTML] Zearalenone disturbs the reproductive-immune axis in pigs: The role of gut microbial metabolites

S Wang, W Fu, X Zhao, X Chang, H Liu, L Zhou, J Li… - Microbiome, 2022 - Springer
Background Exposure to zearalenone (ZEN, a widespread Fusarium mycotoxin) causes
reproductive toxicity and immunotoxicity in farm animals, and it then poses potential threats …

[HTML][HTML] Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization

Y Pi, Y Wu, X Zhang, D Lu, D Han, J Zhao, X Zheng… - Microbiome, 2023 - Springer
Background Low birth weight (LBW) is associated with intestinal inflammation and dysbiosis
after birth. However, the underlying mechanism remains largely unknown. Objective In the …

[HTML][HTML] The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part II: results

RL Hughes, ME Kable, M Marco, NL Keim - Advances in Nutrition, 2019 - Elsevier
The gut microbiota is increasingly implicated in the health and metabolism of its human host.
The host's diet is a major component influencing the composition and function of the gut …

[HTML][HTML] Large animal models: the key to translational discovery in digestive disease research

A Ziegler, L Gonzalez, A Blikslager - Cellular and molecular …, 2016 - Elsevier
Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of
animal models have been instrumental in studying mechanisms of digestive …

[HTML][HTML] Quantified morphology of the cervical and subdiaphragmatic vagus nerves of human, pig, and rat

NA Pelot, GB Goldhagen, JE Cariello… - Frontiers in …, 2020 - frontiersin.org
It is necessary to understand the morphology of the vagus nerve (VN) to design and deliver
effective and selective vagus nerve stimulation (VNS) because nerve morphology influences …

[HTML][HTML] Porcine models of the intestinal microbiota: the translational key to understanding how gut commensals contribute to gastrointestinal disease

EC Rose, AT Blikslager, AL Ziegler - Frontiers in veterinary science, 2022 - frontiersin.org
In the United States, gastrointestinal disorders account for in excess of $130 billion in
healthcare expenditures and 22 million hospitalizations annually. Many of these disorders …

[HTML][HTML] Co-Cultures of Lactobacillus acidophilus and Bacillus subtilis Enhance Mucosal Barrier by Modulating Gut Microbiota-Derived Short-Chain Fatty Acids

Z Xie, M Li, M Qian, Z Yang, X Han - Nutrients, 2022 - mdpi.com
Weaning stress induces intestinal barrier dysfunction and immune dysregulation in
mammals. Various interventions based on the modulation of intestinal microbiota have been …