The exploration of brain epigenomes, which consist of various types of DNA methylation and
covalent histone modifications, is providing new and unprecedented insights into the …

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …

MicroRNAs (miRNAs) regulate various biological processes, but evidence for miRNAs that
control the differentiation program of specific neural cell types has been elusive. To …

The temporally and spatially restricted nature of the differentiation capacity of cells in the
neural lineage has been studied extensively in recent years. Epigenetic control of …

The molecular mechanisms that govern the maturation of oligodendrocyte lineage cells
remain unclear. Emerging studies have shown that N 6-methyladenosine (m 6 A), the most …

Oligodendrocytes provide metabolic and functional support to neuronal cells, rendering
them key players in the functioning of the central nervous system. Oligodendrocytes need to …

Microglia most likely appeared early in evolution as they are not only present in vertebrates,
but are also found in nervous systems of various nonvertebrate organisms. Mammalian …

The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass
from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in …

N-glycosylation is a frequent modification of proteins, essential for all domains of life. N-
glycan biosynthesis is a dynamic, complex, non-templated process, wherein specific …

Myelinating oligodendrocytes are essential for central nervous system (CNS) formation and
function. Their disruption is implicated in numerous neurodevelopmental, neuropsychiatric …