The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …

Transmitter signalling is the universal chemical language of any nervous system, but little is
known about its early evolution. Here, we summarize data about the distribution and …

Neurogenic hypertension is associated with excessive sympathetic nerve activity to the
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …

In view of the high proportion of individuals with resistance to antihypertensive medication
and/or poor compliance or tolerance of this medication, new drugs to treat hypertension are …

The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation
and has a well-recognized role in cardiorespiratory regulation. The CB contains …

Arterial chemoreceptors play a vital role in cardiorespiratory control by providing the brain
with information regarding blood oxygen, carbon dioxide, and pH. The main chemoreceptor …

Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments
or medical conditions with restricted exchange of gases in the lung. The main acute O2 …

Oxygen (O2) is fundamental for cell and whole-body homeostasis. Our understanding of the
adaptive processes that take place in response to a lack of O2 (hypoxia) has progressed …

Pannexins are a family of integral membrane proteins with distinct post-translational
modifications, sub-cellular localization and tissue distribution. Panx1 is the most studied and …