Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

Chromatin accessibility is a hallmark of active transcription and entails ATP-dependent
nucleosome remodeling, which is carried out by complexes such as Brahma-associated …

Regulation of chromatin states involves the dynamic interplay between different histone
modifications to control gene expression. Recent advances have enabled mapping of …

As the field of single-cell transcriptomics matures, research is shifting focus from
phenomenological descriptions of cellular phenotypes to a mechanistic understanding of the …

For more than a century, formalin-fixed paraffin-embedded (FFPE) sample preparation has
been the preferred method for long-term preservation of biological material. However, the …

Genome-wide analysis of transcription factors and epigenomic features is instrumental to
shed light on DNA-templated regulatory processes such as transcription, cellular …

Microglia, the major population of brain‐resident macrophages, are now recognized as a
heterogeneous population comprising several cell subtypes with different (so far mostly …

Gene expression programs result from the collective activity of numerous regulatory factors.
Studying their cooperative mode of action is imperative to understand gene regulation, but …

The ability to comprehensively analyze the chromatin state with single-cell resolution is
crucial for understanding gene regulatory principles in heterogenous tissues or during …