The sheep as a large animal model for the investigation and treatment of human disorders

A Banstola, JNJ Reynolds - Biology, 2022 - mdpi.com
Simple Summary We review the value of large animal models for improving the translation of
biomedical research for human application, focusing primarily on sheep. Abstract An …

Advances in pig models of human diseases

N Hou, X Du, S Wu - Animal Models and Experimental …, 2022 - Wiley Online Library
Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

A compendium of genetic regulatory effects across pig tissues

J Teng, Y Gao, H Yin, Z Bai, S Liu, H Zeng… - Nature …, 2024 - nature.com
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation

KB Ramadi, JC McRae, G Selsing, A Su… - Science robotics, 2023 - science.org
The gut-brain axis, which is mediated via enteric and central neurohormonal signaling, is
known to regulate a broad set of physiological functions from feeding to emotional behavior …

pH‐triggered size‐transformable and bioactivity‐switchable self‐assembling chimeric peptide nanoassemblies for combating drug‐resistant bacteria and biofilms

P Tan, C Wu, Q Tang, T Wang, C Zhou… - Advanced …, 2023 - Wiley Online Library
Drug‐resistant bacteria and biofilm‐associated infections are prominent problems in the
field of antibacterial medicine, seriously affecting human and animal health. Despite the …

Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease

S Yan, X Zheng, Y Lin, C Li, Z Liu, J Li, Z Tu… - Nature Biomedical …, 2023 - nature.com
The monogenic nature of Huntington's disease (HD) and other neurodegenerative diseases
caused by the expansion of glutamine-encoding CAG repeats makes them particularly …

Three-dimensional surface motion capture of multiple freely moving pigs using MAMMAL

L An, J Ren, T Yu, T Hai, Y Jia, Y Liu - Nature Communications, 2023 - nature.com
Understandings of the three-dimensional social behaviors of freely moving large-size
mammals are valuable for both agriculture and life science, yet challenging due to …

Zearalenone disturbs the reproductive-immune axis in pigs: The role of gut microbial metabolites

S Wang, W Fu, X Zhao, X Chang, H Liu, L Zhou, J Li… - Microbiome, 2022 - Springer
Background Exposure to zearalenone (ZEN, a widespread Fusarium mycotoxin) causes
reproductive toxicity and immunotoxicity in farm animals, and it then poses potential threats …

Smart Lubricant Coating with Urease‐Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation

K Li, H Tang, J Peng, S Gao, Z Du… - Advanced Functional …, 2024 - Wiley Online Library
Hydrophilic lubricant coatings with antifouling properties are commercially applied to
urological devices, such as ureteral stents (USs), to inhibit biofilm formation and reduce the …

Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway

X Wang, X Zhang, K Sun, S Wang… - Environmental …, 2022 - Wiley Online Library
Microplastics (MPs) generally refer to the plastic fragments or particles smaller than 5 mm in
diameter, which are closely concerned due to their widespread presence in the …