Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Background: Cancer is a disease characterized by uncontrolled cell growth and
proliferation. It has become a major health problem in the past decades and is now the …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …

Oncotator is a tool for annotating genomic point mutations and short nucleotide
insertions/deletions (indels) with variant‐and gene‐centric information relevant to cancer …

Identifying genetic biomarkers of synthetic lethal drug sensitivity effects provides one
approach to the development of targeted cancer therapies. Mutations in ARID1A represent …

The expression of antigens that are recognized by self-reactive T cells is essential for
immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing …

BACKGROUND Breast cancer 2 (BRCA2)‐associated breast and ovarian cancers are
sensitive to platinum‐based chemotherapy. It is unknown whether BRCA2‐associated …

Cytosine methylation is the major covalent modification of mammalian genomic DNA and
plays important roles in transcriptional regulation. The molecular mechanism underlying the …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …