Pyroptosis: mechanisms and diseases
P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …
innate immunity and disease. The research scope of pyroptosis has expanded with the …
Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy
JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …
Metformin and its benefits for various diseases
Z Lv, Y Guo - Frontiers in endocrinology, 2020 - frontiersin.org
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …
The ménage à trois of autophagy, lipid droplets and liver disease
Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …
building blocks that are indispensable for liver functions. Energy deficiencies are …
Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis
Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …
[PDF][PDF] Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta‐analysis
Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease
(NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically …
(NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically …
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis
Sepsis is a leading cause of death in critical illness, and its pathophysiology varies
depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver …
depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver …
Immunological mechanisms and therapeutic targets of fatty liver diseases
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
Recent insights into the pathogenesis of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …
[HTML][HTML] New targets for NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease
worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and …
worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and …