Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants
M Korenkov, M Zehner, H Cohen-Dvashi… - Immunity, 2023 - cell.com
Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
[HTML][HTML] Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants
S Moriyama, Y Anraku, S Taminishi, Y Adachi… - Nature …, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS)
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …
[HTML][HTML] Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron
M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - BioRxiv, 2022 - biorxiv.org
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to antibody
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …
[HTML][HTML] Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates
As SARS-CoV-2 variants continue evolving, testing updated vaccines in non-human
primates remains important for guiding human clinical practice. To date, such studies have …
primates remains important for guiding human clinical practice. To date, such studies have …
Broad-spectrum pan-genus and pan-family virus vaccines
Although the development and clinical application of SARS-CoV-2 vaccines during the
COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it …
COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it …
Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has been
characterized by the emergence of sets of mutations impacting the virus characteristics, such …
characterized by the emergence of sets of mutations impacting the virus characteristics, such …
[HTML][HTML] A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site
T Onodera, S Kita, Y Adachi, S Moriyama, A Sato… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …
[HTML][HTML] Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations
V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
Prevention of viral escape and increased coverage against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal …
syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal …
A third dose of inactivated vaccine augments the potency, breadth, and duration of anamnestic responses against SARS-CoV-2
Z Jia, K Wang, M Xie, J Wu, Y Hu, Y Zhou… - Protein & …, 2024 - academic.oup.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has lasted for more than four years …
respiratory syndrome coronavirus-2 (SARS-CoV-2) has lasted for more than four years …