Coronavirus disease 2019 (COVID-19) is a highly heterogeneous disease regarding
severity, vulnerability to infection due to comorbidities, and treatment approaches. The …

Chronic stress results in disturbances of body hormones through the neuroendocrine
system. Cancer patients often experience recurrent anxiety and restlessness during disease …

T cell exhaustion plays critical roles in tumor immune evasion. Novel strategies to suppress
immune evasion are in urgent need. We aimed to identify potential compounds to target T …

Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan …

SARS-CoV-2 infection is often associated with severe inflammation, oxidative stress,
hypoxia and impaired physical activity. These factors all together contribute to muscle …

The development of therapies for SARS-CoV-2 infection, based on virus biology and
pathology, and of large-and small-scale randomized controlled trials, have brought forward …

Long-term glucocorticoids can alter sperm motility, vitality, or morphology, disrupting male
reproductive function. This study scrutinized the synergistic benefits of two Egyptian plants …

Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules
secreted by the adrenal gland and regulated by the hypothalamic–pituitary–adrenal (HPA) …

Programmed cell death protein 1 (PD-1) and its ligands, PD-L1/2, control T cell activation
and tolerance. While PD-1 expression is induced upon T cell receptor (TCR) activation or …

Abstract Cadmium (Cd) and lead (Pb) are important environmental endocrine disruptors that
are associated with adverse health problems. However, the effects of co-exposure to Cd and …