[HTML][HTML] PNPLA3 and TLL-1 polymorphisms as potential predictors of disease severity in patients with COVID-19

S Grimaudo, E Amodio, RM Pipitone… - Frontiers in Cell and …, 2021 - frontiersin.org
Albeit the pathogenesis of COVID-19 remains unclear, host's genetic polymorphisms in
genes involved in infection and reinfection, inflammation, or immune stimulation could play a …

G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19)

HC Yang, TH Ma, WY Tjong, A Stern… - Free radical …, 2021 - Taylor & Francis
The COVID-19 pandemic has so far affected more than 45 million people and has caused
over 1 million deaths worldwide. Infection with SARS-CoV-2, the pathogenic agent, which is …

COVID-19 and dentistry in 72 questions: An overview of the literature

S Derruau, J Bouchet, A Nassif, A Baudet… - Journal of Clinical …, 2021 - mdpi.com
The outbreak of Coronavirus Disease 2019 (COVID-19), caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has significantly affected the dental …

Multiple sites on SARS‐CoV‐2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V

K Bollavaram, TH Leeman, MW Lee, A Kulkarni… - Protein …, 2021 - Wiley Online Library
SARS‐CoV‐2 is the coronavirus responsible for the COVID‐19 pandemic. Proteases are
central to the infection process of SARS‐CoV‐2. Cleavage of the spike protein on the virus's …

[HTML][HTML] Genetic evidence and host immune response in persons reinfected with SARS-CoV-2, Brazil

N Fintelman-Rodrigues, APD da Silva… - Emerging infectious …, 2021 - ncbi.nlm.nih.gov
The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
reinfection remain poorly understood. We identified a small cluster of patients in Brazil who …

Innate immune response and inflammasome activation during SARS-CoV-2 infection

M Islamuddin, SA Mustfa, SNMN Ullah, U Omer, K Kato… - Inflammation, 2022 - Springer
The novel coronavirus SARS-CoV-2, responsible for the COVID-19 outbreak, has become a
pandemic threatening millions of lives worldwide. Recently, several vaccine candidates and …

Disease severity in moderate-to-Severe COVID-19 is associated with platelet hyperreactivity and innate immune activation

K Jakobs, L Reinshagen, M Puccini, J Friebel… - Frontiers in …, 2022 - frontiersin.org
Background Hemostasis and inflammation are both dysregulated in patients with moderate-
to-severe coronavirus disease 2019 (COVID-19). Yet, both processes can also be disturbed …

Not so sweet and simple: impacts of SARS-CoV-2 on the β cell

S Ibrahim, GSF Monaco, EK Sims - Islets, 2021 - Taylor & Francis
The link between COVID-19 infection and diabetes has been explored in several studies
since the start of the pandemic, with associations between comorbid diabetes and poorer …

Perspective on therapeutic and diagnostic potential of camel nanobodies for coronavirus disease-19 (COVID-19)

S Bessalah, S Jebahi, N Mejri, I Salhi, T Khorchani… - 3 Biotech, 2021 - Springer
In this paper, we focus on the camelid nanobodies as a revolutionary therapy that can guide
efforts to discover new drugs for Coronavirus disease (COVID-19). The small size property …

The effect of tocilizumab on COVID-19 patient mortality: A systematic review and meta-analysis of randomized controlled trials

WT Lin, SH Hung, CC Lai, CY Wang… - International …, 2021 - Elsevier
Objectives This systematic review and meta-analysis of randomized controlled trials (RCTs)
aimed to investigate the clinical efficacy and safety of tocilizumab for treating patients with …