Negative and ambisense RNA virus ribonucleocapsids: more than protective armor

KR Sabsay, AJW Te Velthuis - Microbiology and Molecular Biology …, 2023 - Am Soc Microbiol
Negative and ambisense RNA viruses are the causative agents of important human
diseases such as influenza, measles, Lassa fever, and Ebola hemorrhagic fever. The viral …

Nucleoprotein as a promising antigen for broadly protective influenza vaccines

A Rak, I Isakova-Sivak, L Rudenko - Vaccines, 2023 - mdpi.com
Annual vaccination is considered as the main preventive strategy against seasonal
influenza. Due to the highly variable nature of major viral antigens, such as hemagglutinin …

Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination

SR Welch, JR Spengler, SC Genzer… - Science …, 2023 - science.org
Nipah virus (NiV) causes a highly lethal disease in humans who present with acute
respiratory or neurological signs. No vaccines against NiV have been approved to date …

Immunoinformatics approach to design multi-epitope-based vaccine against machupo virus taking viral nucleocapsid as a potential candidate

M Naveed, SI Makhdoom, U Ali, K Jabeen, T Aziz… - Vaccines, 2022 - mdpi.com
The family members of Arenaviridae include members of the genus Machupo virus, which
have bi-segmented negative sense RNA inside the envelope and can be transferred to …

Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

AR Garrison, V Moresco, X Zeng, CR Cline… - Nature …, 2024 - nature.com
Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-
based medical countermeasures offer an important strategy to mitigate severe disease …

Characterization of humoral responses to Nipah virus infection in the Syrian Hamster model of disease

FEM Scholte, SE Rodriguez, SR Welch… - The Journal of …, 2023 - academic.oup.com
Nipah virus (NiV) is a highly pathogenic paramyxovirus. The Syrian hamster model
recapitulates key features of human NiV disease and is a critical tool for evaluating antivirals …

[HTML][HTML] Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces …

GS Guerra, D Barriales, G Lorenzo, S Moreno… - Vaccine, 2023 - Elsevier
Schmallenberg Virus (SBV), an arbovirus from the Peribunyaviridae family and
Orthobunyavirus genus, was discovered in late 2011 in Germany and has been circulating …

A molecular perspective for the development of antibodies against the human respiratory syncytial virus

RA Loaiza, RA Ramírez, J Sepúlveda-Alfaro… - Antiviral Research, 2023 - Elsevier
The human respiratory syncytial virus (hRSV) is the leading etiologic agent causing
respiratory infections in infants, children, older adults, and patients with comorbidities. Sixty …

Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex

CM Donnelly, M Stewart, JA Roby, V Sundaramoorthy… - Viruses, 2023 - mdpi.com
Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are
currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction …

Molecular Population Genetics of Aspen Mosaic-Associated Virus in Finland and Sweden

S Nourinejhad Zarghani, R Al Kubrusli, S Iancev… - Viruses, 2023 - mdpi.com
Aspen mosaic-associated virus (AsMaV) is a newly identified Emaravirus, in the family
Fimoviridae, Bunyavirales, associated with mosaic symptoms in aspen trees (Populus …