COVID-19 and the immune response: A multi-phasic approach to the treatment of COVID-19

T Sapir, Z Averch, B Lerman, A Bodzin… - International Journal of …, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral agent that causes
Coronavirus disease 2019 (COVID-19), a disease that causes flu-like symptoms that, when …

Neutrophils during SARS‐CoV‐2 infection: Friend or foe?

FVS Castanheira, P Kubes - Immunological Reviews, 2023 - Wiley Online Library
Summary Coronavirus disease 2019 (COVID‐19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) and has resulted in more than 6 million deaths …

Innate immune cell activation causes lung fibrosis in a humanized model of long COVID

L Cui, Z Fang, CM De Souza, T Lerbs… - Proceedings of the …, 2023 - National Acad Sciences
COVID-19 remains a global pandemic of an unprecedented magnitude with millions of
people now developing “COVID lung fibrosis.” Single-cell transcriptomics of lungs of patients …

Correlation between type I interferon associated factors and COVID-19 severity

D Bencze, T Fekete, K Pázmándi - International Journal of Molecular …, 2022 - mdpi.com
Antiviral type I interferons (IFN) produced in the early phase of viral infections effectively
inhibit viral replication, prevent virus-mediated tissue damages and promote innate and …

Immunothrombosis in acute respiratory dysfunction of COVID-19

XZ Fang, YX Wang, JQ Xu, YJ He, ZK Peng… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is an acute, complex disorder that was caused by a new β-coronavirus severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on current reports, it was …

[HTML][HTML] Exploring the utility of extracellular vesicles in ameliorating viral infection-associated inflammation, cytokine storm and tissue damage

N Pillalamarri, G Ren, L Khan, A Ullah, S Jonnakuti… - Translational …, 2021 - Elsevier
Extracellular vesicles (EVs) have emerged as potential mediators of intercellular
communication. EVs are nano-sized, lipid membrane–bound vesicles that contains …

Multimodal single-cell omics analysis identifies epithelium–immune cell interactions and immune vulnerability associated with sex differences in COVID-19

Y Hou, Y Zhou, MU Gack, JD Lathia… - … and Targeted Therapy, 2021 - nature.com
Sex differences in the susceptibility of SARS-CoV-2 infection and severity have been
controversial, and the underlying mechanisms of COVID-19 in a sex-specific manner remain …

Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes

G Lasso, S Khan, SA Allen, M Mariano… - PLOS Computational …, 2022 - journals.plos.org
The clinical outcome of SARS-CoV-2 infection varies widely between individuals. Machine
learning models can support decision making in healthcare by assessing fatality risk in …

NK cell receptor and ligand composition influences the clearance of SARS-CoV-2

WC Hsieh, EY Lai, YT Liu, YF Wang… - The Journal of …, 2021 - Am Soc Clin Investig
To explore how the immune system controls clearance of SARS-CoV-2, we used a single-
cell, mass cytometry–based proteomics platform to profile the immune systems of 21 patients …

Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients

S André, M Azarias da Silva, M Picard… - Cell Death & …, 2022 - nature.com
In addition to an inflammatory reaction, Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2)-infected patients present lymphopenia, which we recently reported as being …