Controlled human malaria infection: applications, advances, and challenges

DI Stanisic, JS McCarthy, MF Good - Infection and immunity, 2018 - Am Soc Microbiol
Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

Experience and challenges from clinical trials with malaria vaccines in Africa

G Mwangoka, B Ogutu, B Msambichaka, T Mzee… - Malaria journal, 2013 - Springer
Malaria vaccines are considered amongst the most important modalities for potential
elimination of malaria disease and transmission. Research and development in this field has …

Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya

SH Hodgson, E Juma, A Salim, C Magiri, D Njenga… - Malaria journal, 2015 - Springer
Background Controlled human malaria infection (CHMI) studies, in which healthy volunteers
are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines …

Targeting Plasmodium liver stages: better late than never

S Borrmann, K Matuschewski - Trends in molecular medicine, 2011 - cell.com
The worldwide burden of malaria can be substantially reduced using existing public health
interventions. However, elimination of Plasmodium will require fundamentally different …

[HTML][HTML] “At first, I was very afraid”—a qualitative description of participants' views and experiences in the first Human Infection Study in Malawi

NM Toto, K Gooding, BM Kapumba… - Wellcome Open …, 2021 - ncbi.nlm.nih.gov
Background: Human infection studies (HIS) involve deliberately infecting healthy volunteers
with a pathogen in a controlled environment to understand infection and support the …

Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama

CA Boya, L Herrera, HM Guzman… - Journal of Pharmacy …, 2012 - journals.lww.com
Aim: This study was designed for isolating and characterizing antiplasmodial compounds
from marine octocoral-associated bacteria. Materials and Methods: The organic extract of …

An ethics perspective on responsibilities of investigators, sponsors and research participants

R Chilengi - Acta tropica, 2009 - Elsevier
The major international guidelines for health research have come a long way in setting
standards and providing direction on acceptable practices for the conduct of research …

Anti-malarial market and policy surveys in sub-Saharan Africa

G Diap, J Amuasi, I Boakye, AM Sevcsik, B Pecoul - Malaria journal, 2010 - Springer
At a recent meeting (Sept 18, 2009) in which reasons for the limited access to artemisinin-
based combination therapy (ACT) in sub-Saharan Africa were discussed, policy and market …

Protective immunity against malaria by 'natural immunization': a question of dose, parasite diversity, or both?

S Borrmann, K Matuschewski - Current Opinion in Immunology, 2011 - Elsevier
Plasmodium undergoes an obligate liver phase before the onset of malaria, which is caused
exclusively by cyclic propagation of the parasite inside erythrocytes. The diagnostically …

Is vaccine the magic bullet for malaria elimination? A reality check

R Chilengi, J Gitaka - Malaria Journal, 2010 - Springer
Malaria remains a major health burden especially for the developing countries. Despite
concerted efforts at using the current control tools, such as bed nets, anti malarial drugs and …