Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems

FJ Raabe, S Galinski, S Papiol, PG Falkai, A Schmitt… - npj …, 2018 - nature.com
Postmortem studies in patients with schizophrenia (SCZ) have revealed deficits in
myelination, abnormalities in myelin gene expression and altered numbers of …

A comprehensive review of the genetic and biological evidence supports a role for MicroRNA‐137 in the etiology of schizophrenia

K Sakamoto, JJ Crowley - … Journal of Medical Genetics Part B …, 2018 - Wiley Online Library
Since it was first associated with schizophrenia (SCZ) in a 2011 genome‐wide association
study (GWAS), there have been over 100 publications focused on MIR137, the gene …

Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: a tract‐specific analysis study

Y Ohoshi, S Takahashi, S Yamada, T Ishida… - Brain and …, 2019 - Wiley Online Library
Introduction The corpus callosum serves the essential role of relaying cognitive information
between the homologous regions in the left and the right hemispheres of the brain …

Function–structure coupling: White matter functional magnetic resonance imaging hyper‐activation associates with structural integrity reductions in schizophrenia

Y Jiang, M Duan, X Li, H Huang, G Zhao… - Human Brain …, 2021 - Wiley Online Library
White matter (WM) microstructure deficit may be an underlying factor in the brain
dysconnectivity hypothesis of schizophrenia using diffusion tensor imaging (DTI). However …

Mediation of developmental risk factors for psychosis by white matter microstructure in young adults with psychotic experiences

M Drakesmith, A Dutt, L Fonville, S Zammit… - JAMA …, 2016 - jamanetwork.com
Importance White matter (WM) abnormalities have been identified in schizophrenia at the
earliest stages of the disorder. Individuals in the general population with psychotic …

A combined diffusion tensor imaging and magnetic resonance spectroscopy study of patients with schizophrenia

MA Reid, DM White, NV Kraguljac, AC Lahti - Schizophrenia research, 2016 - Elsevier
Diffusion tensor imaging (DTI) studies in schizophrenia consistently show global reductions
in fractional anisotropy (FA), a putative marker of white matter integrity. The cingulum …

[HTML][HTML] Connectivity-enhanced diffusion analysis reveals white matter density disruptions in first episode and chronic schizophrenia

RG Grazioplene, CE Bearden, KL Subotnik… - NeuroImage: Clinical, 2018 - Elsevier
Reduced fractional anisotropy (FA) is a well-established correlate of schizophrenia, but it
remains unclear whether these tensor-based differences are the result of axon damage …

Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra‐high risk for psychosis

TD Kristensen, LB Glenthøj, K Ambrosen… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective Psychosis spectrum disorders are associated with cerebral changes, but the
prognostic value and clinical utility of these findings are unclear. Here, we applied a …

[HTML][HTML] Reduced white matter integrity associated with cognitive deficits in patients with drug-naive first-episode schizophrenia revealed by diffusion tensor imaging

X Peng, R Zhang, W Yan, M Zhou, S Lu… - American journal of …, 2020 - ncbi.nlm.nih.gov
Patients with schizophrenia have shown widespread white matter microstructural
abnormalities and cognitive deficits, but the definitive relationship between white matter and …

Cingulum bundle abnormalities and risk for schizophrenia

J Fitzsimmons, P Rosa, VJ Sydnor, BE Reid… - Schizophrenia …, 2020 - Elsevier
Background The cingulum bundle (CB) is a major white matter fiber tract of the limbic system
that underlies cingulate cortex, passing longitudinally over the corpus callosum. The …