The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …
DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …
during the reoxygenation phase following hypoxia, is well known in a variety of acute …
[HTML][HTML] Fungal infection in co-infected patients with COVID-19: an overview of case reports/case series and systematic review
SS Seyedjavadi, P Bagheri, MJ Nasiri… - Frontiers in …, 2022 - frontiersin.org
Fungal co-infections are frequent in patients with coronavirus disease 2019 (COVID-19) and
can affect patient outcomes and hamper therapeutic efforts. Nonetheless, few studies have …
can affect patient outcomes and hamper therapeutic efforts. Nonetheless, few studies have …
[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
[HTML][HTML] Antiviral molecular targets of essential oils against SARS-CoV-2: A systematic review
Essential oils are potential therapeutics for coronavirus disease 2019 (COVID-19), in which
some of the volatile compounds of essential oils have been well known for their broad …
some of the volatile compounds of essential oils have been well known for their broad …
[HTML][HTML] Case report: sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for …
F Baldi, C Dentone, M Mikulska, D Fenoglio… - Frontiers in …, 2023 - frontiersin.org
COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with
the host immune system and the role of therapy still remains only partly understood. There …
the host immune system and the role of therapy still remains only partly understood. There …
Vibrio parahaemolyticus: Exploring its Incidence in Malaysia and the Potential of Streptomyces sp. as an Anti-Vibrio Agent
As the world recovers from the COVID-19 pandemic, concern remains for future potential
outbreaks because of the persisting effects of climate change, including the proliferation of …
outbreaks because of the persisting effects of climate change, including the proliferation of …
[HTML][HTML] Recent trends in lateral flow immunoassays with optical nanoparticles
Rapid, accurate, and convenient diagnosis is essential for effective disease management.
Various detection methods, such as enzyme-linked immunosorbent assay, have been …
Various detection methods, such as enzyme-linked immunosorbent assay, have been …
Cardiac tissue model of immune-induced dysfunction reveals the role of free mitochondrial DNA and the therapeutic effects of exosomes
Despite tremendous progress in the development of mature heart-on-a-chip models, human
cell–based models of myocardial inflammation are lacking. Here, we bioengineered a …
cell–based models of myocardial inflammation are lacking. Here, we bioengineered a …
[HTML][HTML] Antiviral fibrils of self-assembled peptides with tunable compositions
The lasting threat of viral pandemics necessitates the development of tailorable first-
response antivirals with specific but adaptive architectures for treatment of novel viral …
response antivirals with specific but adaptive architectures for treatment of novel viral …