Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16 Monocytes From COVID-19 Patients

SL Lage, EP Amaral, KL Hilligan, E Laidlaw… - Frontiers in …, 2022 - frontiersin.org
The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is
associated with systemic hyperinflammatory response and immunopathology. Although …

Immune therapy, or antiviral therapy, or both for COVID-19: a systematic review

F Cantini, D Goletti, L Petrone, S Najafi Fard, L Niccoli… - Drugs, 2020 - Springer
Background Based on current evidence, recent guidelines of the National Institute of Health,
USA indicated the use of remdesivir and dexamethasone for the treatment of COVID-19 …

COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease

R Fernandez-Ruiz, JL Paredes, TB Niewold - Translational Research, 2021 - Elsevier
As the world navigates the coronavirus disease 2019 (COVID-19) pandemic, there is a
growing need to assess its impact in patients with autoimmune rheumatic diseases, such as …

Variants in ACE2; potential influences on virus infection and COVID-19 severity

B Bakhshandeh, SG Sorboni, AR Javanmard… - Infection, Genetics and …, 2021 - Elsevier
The third pandemic of coronavirus infection, called COVID-19 disease, was first detected in
November 2019th. Various determinants of disease progression such as age, sex, virus …

[HTML][HTML] The role of Interleukin 6 inhibitors in therapy of severe COVID-19

E Nasonov, M Samsonov - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cytokine storm syndrome (CSS) is a severe complication of inflammatory immune diseases
or treatment of malignancies; it may also appear during the progression of COVID-19. CSS …

Targeting neutrophils to treat acute respiratory distress syndrome in coronavirus disease

CC Chiang, M Korinek, WJ Cheng… - Frontiers in …, 2020 - frontiersin.org
This review describes targeting neutrophils as a potential therapeutic strategy for acute
respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID …

Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID‐19 patients: A systematic review and meta‐analysis

J Peng, M Fu, H Mei, H Zheng, G Liang… - Reviews in medical …, 2022 - Wiley Online Library
As the pandemic progresses, the pathophysiology of coronavirus disease 2019 (COVID‐19)
is becoming clearer and the potential for immunotherapy is increasing. However, clinical …

Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: An observational cohort study

G Bozzi, D Mangioni, F Minoia, S Aliberti… - Journal of Allergy and …, 2021 - Elsevier
Background Immunomodulants have been proposed to mitigate severe acute respiratory
syndrome coronavirus 2–induced cytokine storm, which drives acute respiratory distress …

Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19

FA Khan, I Stewart, L Fabbri, S Moss, K Robinson… - Thorax, 2021 - thorax.bmj.com
Background There is accumulating evidence for an overly activated immune response in
severe COVID-19, with several studies exploring the therapeutic role of immunomodulation …

Blocking IL-1 to prevent respiratory failure in COVID-19

FL Van de Veerdonk, MG Netea - Critical Care, 2020 - Springer
COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild
respiratory tract infection in the majority of individuals, but in some, it can progress into …