In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …

The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators,
CNNMs, are key players in maintaining the homeostasis of magnesium in different organs …

Metaproteomics suffers from the issues of dimensionality and sparsity. Data reduction
methods can maximally identify the relevant subset of significant differential features and …

Background Schizophrenia commonly co-occurs with cardiometabolic and inflammation-
related traits. It is unclear to what extent the comorbidity could be explained by shared …

Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and
intellectual disability. Although the molecular function of CNNM2 is under debate, the protein …

Magnesium (Mg2+) is indispensable for several vital functions, such as neurotransmission,
cardiac conductance, blood glucose, blood pressure regulation, and proper function of more …

Context Genome-wide association studies (GWASs) have been successful in identifying loci
associated with osteoporosis and obesity. However, the findings explain only a small …

Hypomagnesemia, seizures, and intellectual disability (HSMR) syndrome is a rare disorder
caused by mutations in the cyclin M2 (CNNM2) gene. Due to the limited number of cases …

Background Single nucleotide polymorphism (SNP) variants are abundant, persistent and
widely distributed across the genome and are frequently linked to the development of …

Background Clinical and epidemiological studies have suggested systemic lupus
erythematosus (SLE) and rheumatoid arthritis (RA) are comorbidities and common genetic …